Major depressive disorder and comorbid cardiac disease

Is there a depressive subtype with greater cardiovascular morbidity? Results from the STAR*D study

Renerio Fraguas, Dan V. Iosifescu, Jonathan E. Alpert, Stephen R. Wisniewski, Jennifer L. Barkin, Madhukar H. Trivedi, A. John Rush, Maurizio Fava

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The authors conducted exploratory analyses to determine whether specific symptoms of major depressive disorder (MDD) are associated with cardiac disease in 4,041 outpatients at baseline in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. MDD was diagnosed with the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; depressive symptoms were evaluated with the 30-item Inventory of Depressive Symptomatology, Clinician-Rated; and cardiac disease, with the Cumulative Illness Rating Scale. After adjustments for gender, age, ethnicity, education, and employment status, sympathetic arousal and early-morning insomnia were significantly associated with cardiac disease. Prospective studies are warranted to confirm these results.

Original languageEnglish (US)
Pages (from-to)418-425
Number of pages8
JournalPsychosomatics
Volume48
Issue number5
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Major Depressive Disorder
Heart Diseases
Depression
Morbidity
Sleep Initiation and Maintenance Disorders
Arousal
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Therapeutics
Prospective Studies
Education
Equipment and Supplies

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Major depressive disorder and comorbid cardiac disease : Is there a depressive subtype with greater cardiovascular morbidity? Results from the STAR*D study. / Fraguas, Renerio; Iosifescu, Dan V.; Alpert, Jonathan E.; Wisniewski, Stephen R.; Barkin, Jennifer L.; Trivedi, Madhukar H.; Rush, A. John; Fava, Maurizio.

In: Psychosomatics, Vol. 48, No. 5, 09.2007, p. 418-425.

Research output: Contribution to journalArticle

Fraguas, Renerio ; Iosifescu, Dan V. ; Alpert, Jonathan E. ; Wisniewski, Stephen R. ; Barkin, Jennifer L. ; Trivedi, Madhukar H. ; Rush, A. John ; Fava, Maurizio. / Major depressive disorder and comorbid cardiac disease : Is there a depressive subtype with greater cardiovascular morbidity? Results from the STAR*D study. In: Psychosomatics. 2007 ; Vol. 48, No. 5. pp. 418-425.
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