Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood

Luis Hernandez-Garcia, David P. Lewis, Bradford Moffat, Craig A. Branch

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Continuous arterial spin labeling experiments typically use flow-driven adiabatic fast passage inversion of the arterial blood water protons. In this article, we measure the effect of magnetization transfer in blood and how it affects the inversion label. We use modified Bloch equations to model flow-driven adiabatic inversion in the presence of magnetization transfer in blood flowing at velocities from 1 to 30 cm/s in order to explain our findings. Magnetization transfer results in a reduction of the inversion efficiency at the inversion plane of up to 3.65% in the range of velocities examined, as well as faster relaxation of the arterial label in continuous labeling experiments. The two effects combined can result in inversion efficiency reduction of up to 8.91% in the simulated range of velocities. These effects are strongly dependent on the velocity of the flowing blood, with 10 cm/s yielding the largest loss in efficiency due to magnetization transfer effects. Flowing blood phantom experiments confirmed faster relaxation of the inversion label than that predicted by T, decay alone.

Original languageEnglish (US)
Pages (from-to)733-742
Number of pages10
JournalNMR in Biomedicine
Volume20
Issue number8
DOIs
StatePublished - Dec 1 2007

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Keywords

  • Adiabatic inversion
  • Arterial spin labeling
  • Blood flow
  • CBF
  • MRI
  • Magnetization transfer

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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