Maf1 phenotypes and cell physiology

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

As a master regulator of transcription by RNA polymerase (Pol) III, Maf1 represses the synthesis of highly abundant non-coding RNAs as anabolic signals dissipate, as the quality or quantity of nutrients decreases, and under a wide range of cellular and environmental stress conditions. Thus, Maf1 responds to changes in cell physiology to conserve metabolic energy and to help maintain appropriate levels of tRNAs and other essential non-coding RNAs. Studies in different model organisms and cell-based systems show that perturbations of Maf1 can also impact cell physiology and metabolism. These effects are mediated by changes in Pol III transcription and/or by effects of Maf1 on the expression of select Pol II-transcribed genes. Maf1 phenotypes can vary between different systems and are sometimes conflicting as in comparisons between Maf1 KO mice and cultured mammalian cells. These studies are reviewed in an effort to better appreciate the relationship between Maf1 function and cell physiology. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Cell Physiological Phenomena
Physiology
Untranslated RNA
Transcription
Transfer RNA
Phenotype
RNA Polymerase III
Metabolism
Nutrients
Cultured Cells
Genes
Cells
Food

Keywords

  • Cancer
  • Futile cycle
  • Maf1
  • Metabolism
  • RNA polymerase III
  • Tumor suppressor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Maf1 phenotypes and cell physiology. / Willis, Ian M.

In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 01.01.2018.

Research output: Contribution to journalArticle

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