m-Chlorophenylpiperazine challenge in borderline personality disorder: Relationship of neuroendocrine response, behavioral response, and clinical measures

Dan J. Stein, Eric Hollander, Concetta M. DeCaria, Daphne Simeon, Lisa Cohen, Bonnie Aronowitz

Research output: Contribution to journalArticle

24 Scopus citations


We have previously found that a subgroup of patients with impulsive personality disorders respond to m-chlorophenylpiperazine (m-CPP) administration with a distinctive spacy/high behavioral reaction and with increased cortisol responses. In this report we analyzed the relationship between behavioral and neuroendocrine responses to m-CPP in an enlarged sample of patients with borderline personality disorder (BPD), We also assessed the association of behavioral and neuroendocrine responses with clinical symptoms and with m-CPP blood levels. We found that in BPD patients the presence of a spacy/high behavioral response was significantly associated with increased prolactin and cortisol responses to m-CPP. In BPD patients increased m-CPP levels were significantly associated with neuroendocrine hypersensitivity and with a spacy/high behavioral response, while in controls increased m-CPP levels were not significantly associated with neuroendocrine hypersensitivity but were significantly associated with dysphoric behavioral responses. Taken together with previous work on m-CPP in obsessive-compulsive disorder, these results are partially consistent with the hypothesis that compulsive and impulsive symptoms fall at opposite ends of a phenomenologic and neurobiologic spectrum.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalBiological Psychiatry
Issue number6
StatePublished - Sep 15 1996
Externally publishedYes



  • Borderline personality disorder
  • Compulsivity
  • Impulsivity
  • Obsessive-compulsive disorder
  • Serotonin
  • m-chlorophenylpiperazine

ASJC Scopus subject areas

  • Biological Psychiatry

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