Lyme disease: A unique human model for an infectious etiology of rheumatic disease

S. E. Malawista, A. C. Steere, J. A. Hardin

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Lyme disease is a complex immune-mediated multi-system disorder that is infectious in origin and inflammatory or 'rheumatic' in expression. Through its epidemiologic characteristics, large numbers of a seasonally synchronized patient population are readily available for prospective study. Lyme disease has a known clinical onset ('zero time'), marked by the characteristic expanding skin lesion, erythema chronicum migrans, and a clearly defined prearticular phase. At least some manifestations of the disorder are responsive to antibiotics, and the causative agent - a spirochete - is now known. These advantages make Lyme disease unique as a human model for an infectious etiology of rheumatic disease.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalYale Journal of Biology and Medicine
Volume57
Issue number4
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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