Lyme disease

A unique human model for an infectious etiology of rheumatic disease

S. E. Malawista, A. C. Steere, J. A. Hardin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Lyme disease is a complex immune-mediated multi-system disorder that is infectious in origin and inflammatory or 'rheumatic' in expression. Through its epidemiologic characteristics, large numbers of a seasonally synchronized patient population are readily available for prospective study. Lyme disease has a known clinical onset ('zero time'), marked by the characteristic expanding skin lesion, erythema chronicum migrans, and a clearly defined prearticular phase. At least some manifestations of the disorder are responsive to antibiotics, and the causative agent - a spirochete - is now known. These advantages make Lyme disease unique as a human model for an infectious etiology of rheumatic disease.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalYale Journal of Biology and Medicine
Volume57
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Lyme Disease
Rheumatic Diseases
Erythema Chronicum Migrans
Spirochaetales
Antigen-Antibody Complex
Prospective Studies
Anti-Bacterial Agents
Skin
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lyme disease : A unique human model for an infectious etiology of rheumatic disease. / Malawista, S. E.; Steere, A. C.; Hardin, J. A.

In: Yale Journal of Biology and Medicine, Vol. 57, No. 4, 1984, p. 473-477.

Research output: Contribution to journalArticle

Malawista, SE, Steere, AC & Hardin, JA 1984, 'Lyme disease: A unique human model for an infectious etiology of rheumatic disease', Yale Journal of Biology and Medicine, vol. 57, no. 4, pp. 473-477.
Malawista, S. E. ; Steere, A. C. ; Hardin, J. A. / Lyme disease : A unique human model for an infectious etiology of rheumatic disease. In: Yale Journal of Biology and Medicine. 1984 ; Vol. 57, No. 4. pp. 473-477.
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