Lyme disease is a complex immune-mediated multi-system disorder that is infectious in origin and inflammatory or 'rheumatic' in expression. Through its epidemiologic characteristics, large numbers of a seasonally synchronized patient population are readily available for prospective study. Lyme disease has a known clinical onset ('zero time'), marked by the characteristic expanding skin lesion, erythema chronicum migrans, and a clearly defined prearticular phase. At least some manifestations of the disorder are responsive to antibiotics, and the causative agent - a spirochete - is now known. These advantages make Lyme disease unique as a human model for an infectious etiology of rheumatic disease.
|Original language||English (US)|
|Number of pages||5|
|Journal||Yale Journal of Biology and Medicine|
|State||Published - Dec 1 1984|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)