Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity

Rachel Galioto, Kevin C. O’Leary, J. Graham Thomas, Kathryn Demos, Richard B. Lipton, John Gunstad, Jelena M. Pavlovic, Julie Roth, Lucille Rathier, Dale S. Bond

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Pain catastrophizing (PC) is associated with more severe and disabling migraine attacks. However, factors that moderate this relationship are unknown. Failure of inhibitory control (IC), or the ability to suppress automatic or inappropriate responses, may be one such factor given previous research showing a relationship between higher PC and lower IC in non-migraine samples, and research showing reduced IC in migraine. Therefore, we examined whether lower IC interacts with increased PC to predict greater migraine severity as measured by pain intensity, attack frequency, and duration. Methods: Women (n = 105) aged 18–50 years old (M = 38.0 ± 1.2) with overweight/obesity and migraine who were seeking behavioral treatment for weight loss and migraine reduction completed a 28-day smartphone-based headache diary assessing migraine headache severity. Participants then completed a modified computerized Stroop task as a measure of IC and self-report measures of PC (Pain Catastrophizing Scale [PCS]), anxiety, and depression. Linear regression was used to examine independent and joint associations of PC and IC with indices of migraine severity after controlling for age, body mass index (BMI) depression, and anxiety. Results: Participants on average had BMI of 35.1 ± 6.5 kg/m2and reported 5.3 ± 2.6 migraine attacks (8.3 ± 4.4 migraine days) over 28 days that produced moderate pain intensity (5.9 ± 1.4 out of 10) with duration of 20.0 ± 14.2 h. After adjusting for covariates, higher PCS total (β =.241, SE =.14, p =.03) and magnification subscale (β =.311, SE =.51, p <.01) scores were significant independent correlates of longer attack duration. IC interacted with total PCS (β = 1.106, SE =.001, p =.03) rumination (β = 1.098, SE =.001, p =.04), and helplessness (β = 1.026, SE =.001, p =.04) subscale scores to predict headache pain intensity, such that the association between PC and pain intensity became more positive at lower levels of IC. Conclusions: Results showed that lower IC interacted with higher PC, both overall and specific subcomponents, to predict higher pain intensity during migraine attacks. Future studies are needed to determine whether interventions to improve IC could lead to less painful migraine attacks via improvements in PC.

Original languageEnglish (US)
Article number41
JournalJournal of Headache and Pain
Volume18
Issue number1
DOIs
StatePublished - Dec 1 2017

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Catastrophization
Migraine Disorders
Obesity
Pain
Headache
Body Mass Index
Anxiety
Depression
Aptitude
Arthralgia
Research
Self Report
Weight Loss
Linear Models

Keywords

  • Inhibitory control
  • Migraine
  • Obesity
  • Overweight
  • Pain catastrophizing

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity. / Galioto, Rachel; O’Leary, Kevin C.; Thomas, J. Graham; Demos, Kathryn; Lipton, Richard B.; Gunstad, John; Pavlovic, Jelena M.; Roth, Julie; Rathier, Lucille; Bond, Dale S.

In: Journal of Headache and Pain, Vol. 18, No. 1, 41, 01.12.2017.

Research output: Contribution to journalArticle

Galioto, Rachel ; O’Leary, Kevin C. ; Thomas, J. Graham ; Demos, Kathryn ; Lipton, Richard B. ; Gunstad, John ; Pavlovic, Jelena M. ; Roth, Julie ; Rathier, Lucille ; Bond, Dale S. / Lower inhibitory control interacts with greater pain catastrophizing to predict greater pain intensity in women with migraine and overweight/obesity. In: Journal of Headache and Pain. 2017 ; Vol. 18, No. 1.
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AU - O’Leary, Kevin C.

AU - Thomas, J. Graham

AU - Demos, Kathryn

AU - Lipton, Richard B.

AU - Gunstad, John

AU - Pavlovic, Jelena M.

AU - Roth, Julie

AU - Rathier, Lucille

AU - Bond, Dale S.

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KW - Inhibitory control

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