Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging

Hayden William Courtland, Oran D. Kennedy, Yingjie Wu, Ying Gao, Hui (Herb) Sun, Mitchell B. Schaffler, Shoshana Yakar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Studies linking insulin-like growth factor-1 (IGF-1) to age-related bone loss in humans have been reported but remain only correlative. In this investigation, we characterized the bone phenotype of aged WT C57BL/6J male mice in comparison to that of C57BL/ 6J mice with reduced serum IGF-1 levels arising from an igfals gene deletion (ALS knockout (ALSKO)). During the aging process, WT mice showed an increase in fat mass and decrease lean mass while ALSKO mice had stable lean and fat mass values. Skeletal analyses of femora from WT mice revealed an expansion of the marrow area and a significant accumulation of intracortical porosity associated with increased intracortical remodeling. In contrast, ALSKO mice showed only small age-related declines in the amount of cortical bone tissue and minimal intracortical porosity, at 2 years of age. Accordingly, mechanical tests of femora from 2-year-old WT mice revealed reduced stiffness and maximal load when compared to bones from ALSKO mice. We show here that lifelong reductions in serum IGF-1 compromise skeletal size in development leading to slender bones; they are also associated with decreased intracortical bone remodeling and preservation of bone strength during aging.

Original languageEnglish (US)
Pages (from-to)1691-1703
Number of pages13
JournalAge
Volume35
Issue number5
DOIs
StatePublished - Oct 2013
Externally publishedYes

Fingerprint

Bone Remodeling
Somatomedins
Bone and Bones
Knockout Mice
Porosity
Femur
Fats
Gene Deletion
Serum
Inbred C57BL Mouse
Osteoporosis
Bone Marrow
Phenotype

Keywords

  • Aging
  • ALSKO mice
  • Bone
  • Endocrine
  • IGF-1
  • Microcomputed tomography

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Courtland, H. W., Kennedy, O. D., Wu, Y., Gao, Y., Sun, H. H., Schaffler, M. B., & Yakar, S. (2013). Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age, 35(5), 1691-1703. https://doi.org/10.1007/s11357-012-9469-8

Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. / Courtland, Hayden William; Kennedy, Oran D.; Wu, Yingjie; Gao, Ying; Sun, Hui (Herb); Schaffler, Mitchell B.; Yakar, Shoshana.

In: Age, Vol. 35, No. 5, 10.2013, p. 1691-1703.

Research output: Contribution to journalArticle

Courtland, HW, Kennedy, OD, Wu, Y, Gao, Y, Sun, HH, Schaffler, MB & Yakar, S 2013, 'Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging', Age, vol. 35, no. 5, pp. 1691-1703. https://doi.org/10.1007/s11357-012-9469-8
Courtland HW, Kennedy OD, Wu Y, Gao Y, Sun HH, Schaffler MB et al. Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. Age. 2013 Oct;35(5):1691-1703. https://doi.org/10.1007/s11357-012-9469-8
Courtland, Hayden William ; Kennedy, Oran D. ; Wu, Yingjie ; Gao, Ying ; Sun, Hui (Herb) ; Schaffler, Mitchell B. ; Yakar, Shoshana. / Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging. In: Age. 2013 ; Vol. 35, No. 5. pp. 1691-1703.
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