Low-level laser therapy with pulsed infrared laser accelerates third-degree burn healing process in rats

Ali Ezzati, Mohammad Bayat, Sodabe Taheri, Zhaleh Mohsenifar

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This study investigated the influence of pulsed low-level laser therapy (LLLT) on the healing of a third-degree burn in a rat model. Two third-degree burns (distal and proximal) were made in the skin of 74 rats. Rats were divided into four groups. In group 1, the distal burn received LLLT with laser switched off; in groups 2 and 3, distal burns were treated with a 3,000 Hz-pulsed infrared diode laser with 2.3 and 11.7 J/cm2 energy densities, respectively. In group 4, the distal burns were treated topically with 0.2% nitrofurazone. The proximal burn of all groups was considered a control burn. We assessed the response to treatment both microbiologically and macroscopically. The chi-square test showed that the incidence of Staphylococcus epidermidis, Lactobacillus, and diphtheria decreased significantly in laser-treated groups compared with other groups. Independent sample t-test showed that LLLT with 11.7 J/cm2 energy density significantly increased wound-closure rate at 3 and 4 weeks after burning compared with their relevant control burns (p = 0.018 and p = 0.01, respectively). Pulsed LLLT with 11.7 J/cm2/890 nm of a third-degree burn in a rat model significantly increased wound-closure rate compared with control burns.

Original languageEnglish (US)
Pages (from-to)543-554
Number of pages12
JournalJournal of Rehabilitation Research and Development
Volume46
Issue number4
DOIs
StatePublished - Sep 24 2009
Externally publishedYes

Fingerprint

Burns
Lasers
Nitrofurazone
Semiconductor Lasers
Diphtheria
Staphylococcus epidermidis
Wounds and Injuries
Lactobacillus
Chi-Square Distribution
Low-Level Light Therapy
Skin
Incidence
Therapeutics

Keywords

  • Basic science
  • Burn
  • In vivo
  • Infrared diode laser
  • Low-level laser therapy
  • Microbiology
  • Rat
  • Third-degree burn
  • Wound contraction
  • Wound healing

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Low-level laser therapy with pulsed infrared laser accelerates third-degree burn healing process in rats. / Ezzati, Ali; Bayat, Mohammad; Taheri, Sodabe; Mohsenifar, Zhaleh.

In: Journal of Rehabilitation Research and Development, Vol. 46, No. 4, 24.09.2009, p. 543-554.

Research output: Contribution to journalArticle

@article{b811b6aac7264a53bfd9e4b42b5c5851,
title = "Low-level laser therapy with pulsed infrared laser accelerates third-degree burn healing process in rats",
abstract = "This study investigated the influence of pulsed low-level laser therapy (LLLT) on the healing of a third-degree burn in a rat model. Two third-degree burns (distal and proximal) were made in the skin of 74 rats. Rats were divided into four groups. In group 1, the distal burn received LLLT with laser switched off; in groups 2 and 3, distal burns were treated with a 3,000 Hz-pulsed infrared diode laser with 2.3 and 11.7 J/cm2 energy densities, respectively. In group 4, the distal burns were treated topically with 0.2{\%} nitrofurazone. The proximal burn of all groups was considered a control burn. We assessed the response to treatment both microbiologically and macroscopically. The chi-square test showed that the incidence of Staphylococcus epidermidis, Lactobacillus, and diphtheria decreased significantly in laser-treated groups compared with other groups. Independent sample t-test showed that LLLT with 11.7 J/cm2 energy density significantly increased wound-closure rate at 3 and 4 weeks after burning compared with their relevant control burns (p = 0.018 and p = 0.01, respectively). Pulsed LLLT with 11.7 J/cm2/890 nm of a third-degree burn in a rat model significantly increased wound-closure rate compared with control burns.",
keywords = "Basic science, Burn, In vivo, Infrared diode laser, Low-level laser therapy, Microbiology, Rat, Third-degree burn, Wound contraction, Wound healing",
author = "Ali Ezzati and Mohammad Bayat and Sodabe Taheri and Zhaleh Mohsenifar",
year = "2009",
month = "9",
day = "24",
doi = "10.1682/JRRD.2008.09.0121",
language = "English (US)",
volume = "46",
pages = "543--554",
journal = "Journal of rehabilitation R&D",
issn = "0748-7711",
publisher = "Rehabilitation Research and Development Service",
number = "4",

}

TY - JOUR

T1 - Low-level laser therapy with pulsed infrared laser accelerates third-degree burn healing process in rats

AU - Ezzati, Ali

AU - Bayat, Mohammad

AU - Taheri, Sodabe

AU - Mohsenifar, Zhaleh

PY - 2009/9/24

Y1 - 2009/9/24

N2 - This study investigated the influence of pulsed low-level laser therapy (LLLT) on the healing of a third-degree burn in a rat model. Two third-degree burns (distal and proximal) were made in the skin of 74 rats. Rats were divided into four groups. In group 1, the distal burn received LLLT with laser switched off; in groups 2 and 3, distal burns were treated with a 3,000 Hz-pulsed infrared diode laser with 2.3 and 11.7 J/cm2 energy densities, respectively. In group 4, the distal burns were treated topically with 0.2% nitrofurazone. The proximal burn of all groups was considered a control burn. We assessed the response to treatment both microbiologically and macroscopically. The chi-square test showed that the incidence of Staphylococcus epidermidis, Lactobacillus, and diphtheria decreased significantly in laser-treated groups compared with other groups. Independent sample t-test showed that LLLT with 11.7 J/cm2 energy density significantly increased wound-closure rate at 3 and 4 weeks after burning compared with their relevant control burns (p = 0.018 and p = 0.01, respectively). Pulsed LLLT with 11.7 J/cm2/890 nm of a third-degree burn in a rat model significantly increased wound-closure rate compared with control burns.

AB - This study investigated the influence of pulsed low-level laser therapy (LLLT) on the healing of a third-degree burn in a rat model. Two third-degree burns (distal and proximal) were made in the skin of 74 rats. Rats were divided into four groups. In group 1, the distal burn received LLLT with laser switched off; in groups 2 and 3, distal burns were treated with a 3,000 Hz-pulsed infrared diode laser with 2.3 and 11.7 J/cm2 energy densities, respectively. In group 4, the distal burns were treated topically with 0.2% nitrofurazone. The proximal burn of all groups was considered a control burn. We assessed the response to treatment both microbiologically and macroscopically. The chi-square test showed that the incidence of Staphylococcus epidermidis, Lactobacillus, and diphtheria decreased significantly in laser-treated groups compared with other groups. Independent sample t-test showed that LLLT with 11.7 J/cm2 energy density significantly increased wound-closure rate at 3 and 4 weeks after burning compared with their relevant control burns (p = 0.018 and p = 0.01, respectively). Pulsed LLLT with 11.7 J/cm2/890 nm of a third-degree burn in a rat model significantly increased wound-closure rate compared with control burns.

KW - Basic science

KW - Burn

KW - In vivo

KW - Infrared diode laser

KW - Low-level laser therapy

KW - Microbiology

KW - Rat

KW - Third-degree burn

KW - Wound contraction

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=70349235480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349235480&partnerID=8YFLogxK

U2 - 10.1682/JRRD.2008.09.0121

DO - 10.1682/JRRD.2008.09.0121

M3 - Article

C2 - 19882488

AN - SCOPUS:70349235480

VL - 46

SP - 543

EP - 554

JO - Journal of rehabilitation R&D

JF - Journal of rehabilitation R&D

SN - 0748-7711

IS - 4

ER -