Low-grade papillary adenocarcinoma of the palate: The significance of distinguishing it from polymorphous low-grade adenocarcinoma

Jacob B. Hunter, Richard V. Smith, Margaret Brandwein-Gensler

Research output: Contribution to journalReview article

11 Scopus citations


Low-grade papillary adenocarcinoma (LGPA) represents a relatively rare histological variant of polymorphous low-grade adenocarcinoma (PLGA). There has been a debate as to whether LGPA is associated with greater aggressive potential compared to PLGA; this is further obfuscated by the fact that diagnostic criteria for LGPA have not been well-defined. We believe that this is the first report of a patient with LGPA who developed metastases to the femur and scalp. We review the published evidence for classifying LGPA as distinct from PLGA. The weight of published data does support the idea that LGPA is oncologically distinct from LGPA. However, as uniform diagnostic criteria are lacking, we suggest a cut-off value of 10% or greater papillary formation as being necessary to separate LGPA from PLGA.

Original languageEnglish (US)
Pages (from-to)316-323
Number of pages8
JournalHead and Neck Pathology
Issue number4
StatePublished - Dec 1 2008



  • Low-grade papillary adenocarcinoma
  • Oral salivary gland tumor
  • Polymorphous low-grade adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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