Low-grade glioma: A rare second tumor in retinoblastoma survivors

Nagma Dalvi, Ruth A. Kleinerman, Sidnei Epelman, David H. Abramson, Ira J. Dunkel

Research output: Contribution to journalArticlepeer-review

Abstract

Retinoblastoma survivors with a germline RB1 mutation are at elevated risk for secondary (nonocular) malignancy, but their risk for low-grade glioma (LGG) is unknown. We performed a retrospective review of the Memorial Sloan Kettering Cancer Center and the NCI databases that revealed that three of the 837 5-year survivors of hereditary retinoblastoma were diagnosed with an LGG and a fourth patient (but unilateral and without a germline mutation) was identified at another center. Retinoblastoma survivors may be at increased risk for LGG.

Original languageEnglish (US)
Article numbere28770
JournalPediatric Blood and Cancer
Volume68
Issue number2
DOIs
StatePublished - Feb 2021
Externally publishedYes

Keywords

  • low-grade glioma
  • retinoblastoma
  • second cancers
  • survivorship

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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