TY - JOUR
T1 - Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis
AU - Wilson, F. Perry
AU - Bachhuber, Marcus A.
AU - Caroff, Daniel
AU - Adler, Rebecca
AU - Fish, Douglas
AU - Berns, Jeffrey
PY - 2012/4
Y1 - 2012/4
N2 - Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.
AB - Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.
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U2 - 10.1128/AAC.05987-11
DO - 10.1128/AAC.05987-11
M3 - Article
C2 - 22290968
AN - SCOPUS:84858668855
SN - 0066-4804
VL - 56
SP - 2178
EP - 2180
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -
