Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis

F. Perry Wilson, Marcus A. Bachhuber, Daniel Caroff, Rebecca Adler, Douglas Fish, Jeffrey Berns

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.

Original languageEnglish (US)
Pages (from-to)2178-2180
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

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Dialysis Solutions
Renal Dialysis
Pseudomonas aeruginosa
Serum
cefepime
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis. / Wilson, F. Perry; Bachhuber, Marcus A.; Caroff, Daniel; Adler, Rebecca; Fish, Douglas; Berns, Jeffrey.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 4, 04.2012, p. 2178-2180.

Research output: Contribution to journalArticle

Wilson, F. Perry ; Bachhuber, Marcus A. ; Caroff, Daniel ; Adler, Rebecca ; Fish, Douglas ; Berns, Jeffrey. / Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 4. pp. 2178-2180.
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