Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis

F. Perry Wilson, Marcus A. Bachhuber, Daniel Caroff, Rebecca Adler, Douglas Fish, Jeffrey Berns

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.

Original languageEnglish (US)
Pages (from-to)2178-2180
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 1 2012

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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