Low arterial compliance in young African-American males

Adrienne S. Zion, Vernon Bond, Richard G. Adams, Deborah Williams, Robert E. Fullilove, Richard P. Sloan, Matthew N. Bartels, John A. Downey, Ronald E. De Meersman

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Hypertension remains a common public health challenge because of its prevalence and increase in co-morbid cardiovascular diseases. Black males have disproportionate pathophysiological consequences of hypertension compared with any other group in the United States. Alterations in arterial wall compliance and autonomic function often precede the onset of disease. Accordingly, our purpose was to investigate whether differences exist in arterial compliance and autonomic function between young, healthy African-American males without evidence of hypertension and age- and gender-matched non-African-American males. All procedures were carried out noninvasively following rest. Arterial compliance was calculated as the integrated area starting at the well-defined nadir of the incisura of the dicrotic notch to the end of diastole of the radial artery pulse wave. Power spectral analysis of heart rate and blood pressure variability provided distributions representative of parasympathetic and sympathetic modulations and sympathovagal balance. Baroreflex sensitivity (BRS) was calculated using the sequence method. Thirty-two African-American and twenty-nine non-African-American males were comparable in anthropometrics and negative family history of hypertension. t-Tests revealed lower arterial compliance (5.8 ± 2.4 vs. 8.6 ± 4.0 mmHg·s; P = 0.0017), parasympathetic modulation (8.9 ± 1.1 vs. 9.7 ± 1.1 ln ms2; P = 0.0063), and BRS (13.7 ± 7.3 vs. 21.1 ± 8.5 ms/mmHg; P = 0.0007) and higher sympathovagal balance (2.9 ± 3.2 vs. 1.5 ± 1.1; P = 0.03) in the African-American group. In summary, differences exist in arterial compliance and autonomic balance in African-American males. These alterations may be antecedent markers of disease and valuable in the detection of degenerative cardiovascular processes in individuals at risk.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume285
Issue number2 54-2
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

African Americans
Compliance
Hypertension
Baroreflex
Radial Artery
Diastole
Pulse
Cardiovascular Diseases
Public Health
Heart Rate
Blood Pressure

Keywords

  • Arterial hypertension
  • Autonomic nervous system
  • Baroreflex

ASJC Scopus subject areas

  • Physiology

Cite this

Zion, A. S., Bond, V., Adams, R. G., Williams, D., Fullilove, R. E., Sloan, R. P., ... De Meersman, R. E. (2003). Low arterial compliance in young African-American males. American Journal of Physiology - Heart and Circulatory Physiology, 285(2 54-2).

Low arterial compliance in young African-American males. / Zion, Adrienne S.; Bond, Vernon; Adams, Richard G.; Williams, Deborah; Fullilove, Robert E.; Sloan, Richard P.; Bartels, Matthew N.; Downey, John A.; De Meersman, Ronald E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 285, No. 2 54-2, 01.08.2003.

Research output: Contribution to journalArticle

Zion, AS, Bond, V, Adams, RG, Williams, D, Fullilove, RE, Sloan, RP, Bartels, MN, Downey, JA & De Meersman, RE 2003, 'Low arterial compliance in young African-American males', American Journal of Physiology - Heart and Circulatory Physiology, vol. 285, no. 2 54-2.
Zion AS, Bond V, Adams RG, Williams D, Fullilove RE, Sloan RP et al. Low arterial compliance in young African-American males. American Journal of Physiology - Heart and Circulatory Physiology. 2003 Aug 1;285(2 54-2).
Zion, Adrienne S. ; Bond, Vernon ; Adams, Richard G. ; Williams, Deborah ; Fullilove, Robert E. ; Sloan, Richard P. ; Bartels, Matthew N. ; Downey, John A. ; De Meersman, Ronald E. / Low arterial compliance in young African-American males. In: American Journal of Physiology - Heart and Circulatory Physiology. 2003 ; Vol. 285, No. 2 54-2.
@article{79f92a40bf7941d686556f78029a9ca6,
title = "Low arterial compliance in young African-American males",
abstract = "Hypertension remains a common public health challenge because of its prevalence and increase in co-morbid cardiovascular diseases. Black males have disproportionate pathophysiological consequences of hypertension compared with any other group in the United States. Alterations in arterial wall compliance and autonomic function often precede the onset of disease. Accordingly, our purpose was to investigate whether differences exist in arterial compliance and autonomic function between young, healthy African-American males without evidence of hypertension and age- and gender-matched non-African-American males. All procedures were carried out noninvasively following rest. Arterial compliance was calculated as the integrated area starting at the well-defined nadir of the incisura of the dicrotic notch to the end of diastole of the radial artery pulse wave. Power spectral analysis of heart rate and blood pressure variability provided distributions representative of parasympathetic and sympathetic modulations and sympathovagal balance. Baroreflex sensitivity (BRS) was calculated using the sequence method. Thirty-two African-American and twenty-nine non-African-American males were comparable in anthropometrics and negative family history of hypertension. t-Tests revealed lower arterial compliance (5.8 ± 2.4 vs. 8.6 ± 4.0 mmHg·s; P = 0.0017), parasympathetic modulation (8.9 ± 1.1 vs. 9.7 ± 1.1 ln ms2; P = 0.0063), and BRS (13.7 ± 7.3 vs. 21.1 ± 8.5 ms/mmHg; P = 0.0007) and higher sympathovagal balance (2.9 ± 3.2 vs. 1.5 ± 1.1; P = 0.03) in the African-American group. In summary, differences exist in arterial compliance and autonomic balance in African-American males. These alterations may be antecedent markers of disease and valuable in the detection of degenerative cardiovascular processes in individuals at risk.",
keywords = "Arterial hypertension, Autonomic nervous system, Baroreflex",
author = "Zion, {Adrienne S.} and Vernon Bond and Adams, {Richard G.} and Deborah Williams and Fullilove, {Robert E.} and Sloan, {Richard P.} and Bartels, {Matthew N.} and Downey, {John A.} and {De Meersman}, {Ronald E.}",
year = "2003",
month = "8",
day = "1",
language = "English (US)",
volume = "285",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "2 54-2",

}

TY - JOUR

T1 - Low arterial compliance in young African-American males

AU - Zion, Adrienne S.

AU - Bond, Vernon

AU - Adams, Richard G.

AU - Williams, Deborah

AU - Fullilove, Robert E.

AU - Sloan, Richard P.

AU - Bartels, Matthew N.

AU - Downey, John A.

AU - De Meersman, Ronald E.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Hypertension remains a common public health challenge because of its prevalence and increase in co-morbid cardiovascular diseases. Black males have disproportionate pathophysiological consequences of hypertension compared with any other group in the United States. Alterations in arterial wall compliance and autonomic function often precede the onset of disease. Accordingly, our purpose was to investigate whether differences exist in arterial compliance and autonomic function between young, healthy African-American males without evidence of hypertension and age- and gender-matched non-African-American males. All procedures were carried out noninvasively following rest. Arterial compliance was calculated as the integrated area starting at the well-defined nadir of the incisura of the dicrotic notch to the end of diastole of the radial artery pulse wave. Power spectral analysis of heart rate and blood pressure variability provided distributions representative of parasympathetic and sympathetic modulations and sympathovagal balance. Baroreflex sensitivity (BRS) was calculated using the sequence method. Thirty-two African-American and twenty-nine non-African-American males were comparable in anthropometrics and negative family history of hypertension. t-Tests revealed lower arterial compliance (5.8 ± 2.4 vs. 8.6 ± 4.0 mmHg·s; P = 0.0017), parasympathetic modulation (8.9 ± 1.1 vs. 9.7 ± 1.1 ln ms2; P = 0.0063), and BRS (13.7 ± 7.3 vs. 21.1 ± 8.5 ms/mmHg; P = 0.0007) and higher sympathovagal balance (2.9 ± 3.2 vs. 1.5 ± 1.1; P = 0.03) in the African-American group. In summary, differences exist in arterial compliance and autonomic balance in African-American males. These alterations may be antecedent markers of disease and valuable in the detection of degenerative cardiovascular processes in individuals at risk.

AB - Hypertension remains a common public health challenge because of its prevalence and increase in co-morbid cardiovascular diseases. Black males have disproportionate pathophysiological consequences of hypertension compared with any other group in the United States. Alterations in arterial wall compliance and autonomic function often precede the onset of disease. Accordingly, our purpose was to investigate whether differences exist in arterial compliance and autonomic function between young, healthy African-American males without evidence of hypertension and age- and gender-matched non-African-American males. All procedures were carried out noninvasively following rest. Arterial compliance was calculated as the integrated area starting at the well-defined nadir of the incisura of the dicrotic notch to the end of diastole of the radial artery pulse wave. Power spectral analysis of heart rate and blood pressure variability provided distributions representative of parasympathetic and sympathetic modulations and sympathovagal balance. Baroreflex sensitivity (BRS) was calculated using the sequence method. Thirty-two African-American and twenty-nine non-African-American males were comparable in anthropometrics and negative family history of hypertension. t-Tests revealed lower arterial compliance (5.8 ± 2.4 vs. 8.6 ± 4.0 mmHg·s; P = 0.0017), parasympathetic modulation (8.9 ± 1.1 vs. 9.7 ± 1.1 ln ms2; P = 0.0063), and BRS (13.7 ± 7.3 vs. 21.1 ± 8.5 ms/mmHg; P = 0.0007) and higher sympathovagal balance (2.9 ± 3.2 vs. 1.5 ± 1.1; P = 0.03) in the African-American group. In summary, differences exist in arterial compliance and autonomic balance in African-American males. These alterations may be antecedent markers of disease and valuable in the detection of degenerative cardiovascular processes in individuals at risk.

KW - Arterial hypertension

KW - Autonomic nervous system

KW - Baroreflex

UR - http://www.scopus.com/inward/record.url?scp=0037962300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037962300&partnerID=8YFLogxK

M3 - Article

C2 - 12738618

AN - SCOPUS:0037962300

VL - 285

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 2 54-2

ER -