Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction

N. L. Gerber, J. A. Hardin, T. M. Chused, A. D. Steinberg

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The ability of lymphoid cells from NZB/W female mice to induce graft versus host disease (GVH) was studied by injections into newborn C3H/HeJ mice followed 9 days later by the Simonsen spleen weight:body weight assay. Spleen cells, 5 x 106, led to increasing GVH with increasing age until about 5 months of age, after which a decline in GVH was observed. The heightened responsiveness of 4.5 month or 6 month NZB/W spleen cells could be suppressed by syngeneic lymphoid cells from mice under 2 months of age but not from mice 12 months of age. This suppressive function of young thymocytes and spleen cells increased with increasing cell dose. The suppressive function gradually decreased in thymocyte populations between 1 and 4 months of age. Nevertheless, 4 month thymocytes that no longer demonstrated suppressor function were able to synergize with 12 month spleen cells. These studies suggest that suppressor cells are lost as NZB/W mice age and that suppressor function is lost before helper function.

Original languageEnglish (US)
Pages (from-to)1618-1625
Number of pages8
JournalJournal of Immunology
Volume113
Issue number5
StatePublished - 1974
Externally publishedYes

Fingerprint

Graft vs Host Reaction
Inbred NZB Mouse
Spleen
Graft vs Host Disease
Thymocytes
Lymphocytes
Inbred C3H Mouse
Body Weight
Weights and Measures
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Gerber, N. L., Hardin, J. A., Chused, T. M., & Steinberg, A. D. (1974). Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction. Journal of Immunology, 113(5), 1618-1625.

Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction. / Gerber, N. L.; Hardin, J. A.; Chused, T. M.; Steinberg, A. D.

In: Journal of Immunology, Vol. 113, No. 5, 1974, p. 1618-1625.

Research output: Contribution to journalArticle

Gerber, NL, Hardin, JA, Chused, TM & Steinberg, AD 1974, 'Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction', Journal of Immunology, vol. 113, no. 5, pp. 1618-1625.
Gerber NL, Hardin JA, Chused TM, Steinberg AD. Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction. Journal of Immunology. 1974;113(5):1618-1625.
Gerber, N. L. ; Hardin, J. A. ; Chused, T. M. ; Steinberg, A. D. / Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction. In: Journal of Immunology. 1974 ; Vol. 113, No. 5. pp. 1618-1625.
@article{1f33ccdb67574882ad15868b476510d4,
title = "Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction",
abstract = "The ability of lymphoid cells from NZB/W female mice to induce graft versus host disease (GVH) was studied by injections into newborn C3H/HeJ mice followed 9 days later by the Simonsen spleen weight:body weight assay. Spleen cells, 5 x 106, led to increasing GVH with increasing age until about 5 months of age, after which a decline in GVH was observed. The heightened responsiveness of 4.5 month or 6 month NZB/W spleen cells could be suppressed by syngeneic lymphoid cells from mice under 2 months of age but not from mice 12 months of age. This suppressive function of young thymocytes and spleen cells increased with increasing cell dose. The suppressive function gradually decreased in thymocyte populations between 1 and 4 months of age. Nevertheless, 4 month thymocytes that no longer demonstrated suppressor function were able to synergize with 12 month spleen cells. These studies suggest that suppressor cells are lost as NZB/W mice age and that suppressor function is lost before helper function.",
author = "Gerber, {N. L.} and Hardin, {J. A.} and Chused, {T. M.} and Steinberg, {A. D.}",
year = "1974",
language = "English (US)",
volume = "113",
pages = "1618--1625",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "5",

}

TY - JOUR

T1 - Loss with age in NZB/W mice of thymic suppressor cells in the graft vs host reaction

AU - Gerber, N. L.

AU - Hardin, J. A.

AU - Chused, T. M.

AU - Steinberg, A. D.

PY - 1974

Y1 - 1974

N2 - The ability of lymphoid cells from NZB/W female mice to induce graft versus host disease (GVH) was studied by injections into newborn C3H/HeJ mice followed 9 days later by the Simonsen spleen weight:body weight assay. Spleen cells, 5 x 106, led to increasing GVH with increasing age until about 5 months of age, after which a decline in GVH was observed. The heightened responsiveness of 4.5 month or 6 month NZB/W spleen cells could be suppressed by syngeneic lymphoid cells from mice under 2 months of age but not from mice 12 months of age. This suppressive function of young thymocytes and spleen cells increased with increasing cell dose. The suppressive function gradually decreased in thymocyte populations between 1 and 4 months of age. Nevertheless, 4 month thymocytes that no longer demonstrated suppressor function were able to synergize with 12 month spleen cells. These studies suggest that suppressor cells are lost as NZB/W mice age and that suppressor function is lost before helper function.

AB - The ability of lymphoid cells from NZB/W female mice to induce graft versus host disease (GVH) was studied by injections into newborn C3H/HeJ mice followed 9 days later by the Simonsen spleen weight:body weight assay. Spleen cells, 5 x 106, led to increasing GVH with increasing age until about 5 months of age, after which a decline in GVH was observed. The heightened responsiveness of 4.5 month or 6 month NZB/W spleen cells could be suppressed by syngeneic lymphoid cells from mice under 2 months of age but not from mice 12 months of age. This suppressive function of young thymocytes and spleen cells increased with increasing cell dose. The suppressive function gradually decreased in thymocyte populations between 1 and 4 months of age. Nevertheless, 4 month thymocytes that no longer demonstrated suppressor function were able to synergize with 12 month spleen cells. These studies suggest that suppressor cells are lost as NZB/W mice age and that suppressor function is lost before helper function.

UR - http://www.scopus.com/inward/record.url?scp=0016197975&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016197975&partnerID=8YFLogxK

M3 - Article

C2 - 4153571

AN - SCOPUS:0016197975

VL - 113

SP - 1618

EP - 1625

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 5

ER -