Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Susmita Kaushik, Esperanza Arias-Perez, Hyokjoon Kwon, Nuria Martinez Lopez, Diana Athonvarangkul, Srabani Sahu, Gary J. Schwartz, Jeffrey E. Pessin, Rajat Singh

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α-melanocyte-stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and α-MSH levels, and aged-mice phenocopy, the adiposity and lipolytic defect observed in POMC neuron autophagy-null mice. Intraperitoneal isoproterenol restores lipolysis in both models, demonstrating normal adipocyte catecholamine responsiveness. We propose that an unconventional, autophagosome-mediated form of secretion in POMC neurons controls energy balance by regulating α-MSH production. Modulating hypothalamic autophagy might have implications for preventing obesity and metabolic syndrome of ageing.

Original languageEnglish (US)
Pages (from-to)258-265
Number of pages8
JournalEMBO Reports
Volume13
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Melanocyte-Stimulating Hormones
Pro-Opiomelanocortin
Lipolysis
Autophagy
Neurons
Aging of materials
Adiposity
Energy balance
Isoproterenol
Homeostasis
Catecholamines
Glucose
Defects
Adipocytes
Obesity

Keywords

  • ageing
  • autophagy
  • hypothalamus
  • obesity
  • POMC

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Kaushik, S., Arias-Perez, E., Kwon, H., Lopez, N. M., Athonvarangkul, D., Sahu, S., ... Singh, R. (2012). Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. EMBO Reports, 13(3), 258-265. https://doi.org/10.1038/embor.2011.260

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. / Kaushik, Susmita; Arias-Perez, Esperanza; Kwon, Hyokjoon; Lopez, Nuria Martinez; Athonvarangkul, Diana; Sahu, Srabani; Schwartz, Gary J.; Pessin, Jeffrey E.; Singh, Rajat.

In: EMBO Reports, Vol. 13, No. 3, 03.2012, p. 258-265.

Research output: Contribution to journalArticle

Kaushik, Susmita ; Arias-Perez, Esperanza ; Kwon, Hyokjoon ; Lopez, Nuria Martinez ; Athonvarangkul, Diana ; Sahu, Srabani ; Schwartz, Gary J. ; Pessin, Jeffrey E. ; Singh, Rajat. / Loss of autophagy in hypothalamic POMC neurons impairs lipolysis. In: EMBO Reports. 2012 ; Vol. 13, No. 3. pp. 258-265.
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