Longitudinal association of hemostatic factors with risk for cancers of the breast, colorectum, and lung among postmenopausal women

Geoffrey C. Kabat, Christian R. Salazar, Oleg Zaslavsky, Dorothy S. Lane, Thomas E. Rohan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to examine whether hemostatic factors associated with coagulation and inflammation pathways are associated with cancer risk in postmenopausal women. We used data from the Women's Health Initiative study to examine the association of plasma fibrinogen levels, factor VII antigen activity, and factor VII concentration measured at baseline and during follow-up with the risk for cancers of the breast, colorectum, and lung. Among 5287 women who were followed up for a median of 11.4 years, 275 cases of breast cancer, 102 cases of colorectal cancer, and 90 cases of lung cancer were identified. Cox proportional hazards models were used to estimate hazard ratios and 95%confidence intervals for the association of hemostatic factors with each cancer. Hemostatic factors were not associated with breast cancer in either baseline or longitudinal analyses. Baseline hemostatic factors showed weak associations with colorectal cancer; however, no association was seen in longitudinal analyses. Fibrinogen was positively associated with lung cancer in both baseline and longitudinal analyses; the association was seen only in never and former smokers, not in current smokers. We found no evidence of an association between hemostatic factors and breast or colorectal cancer in postmenopausal women. The positive association of fibrinogen levels with lung cancer requires confirmation in larger studies. European Journal of Cancer Prevention 25:449-456

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalEuropean Journal of Cancer Prevention
Volume25
Issue number5
DOIs
StatePublished - 2016

Fingerprint

Hemostatics
Lung Neoplasms
Breast Neoplasms
Fibrinogen
Colorectal Neoplasms
Factor VII
Neoplasms
Women's Health
Proportional Hazards Models
Confidence Intervals
Inflammation
Antigens

Keywords

  • Breast cancer
  • Colorectal cancer
  • Factor VII antigen activity
  • Factor VII concentration
  • Lung cancer
  • Postmenopausal women
  • Repeat measurements
  • Serum fibrinogen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Longitudinal association of hemostatic factors with risk for cancers of the breast, colorectum, and lung among postmenopausal women. / Kabat, Geoffrey C.; Salazar, Christian R.; Zaslavsky, Oleg; Lane, Dorothy S.; Rohan, Thomas E.

In: European Journal of Cancer Prevention, Vol. 25, No. 5, 2016, p. 449-456.

Research output: Contribution to journalArticle

Kabat, Geoffrey C. ; Salazar, Christian R. ; Zaslavsky, Oleg ; Lane, Dorothy S. ; Rohan, Thomas E. / Longitudinal association of hemostatic factors with risk for cancers of the breast, colorectum, and lung among postmenopausal women. In: European Journal of Cancer Prevention. 2016 ; Vol. 25, No. 5. pp. 449-456.
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