Long-term outcomes of childhood onset nephrotic syndrome

Rebecca Hjorten, Zohra Anwar, Kimberly J. Reidy

Research output: Contribution to journalShort survey

8 Citations (Scopus)

Abstract

There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

Original languageEnglish (US)
Article number53
JournalFrontiers in Pediatrics
Volume4
Issue numberMAY
DOIs
StatePublished - May 1 2016

Fingerprint

Nephrotic Syndrome
Steroids
Dyslipidemias
Cataract
Infertility
Osteoporosis
Chronic Kidney Failure
Obesity
Biomarkers
Mutation
Growth

Keywords

  • Children
  • Focal glomerulosclerosis
  • Genetics
  • Minimal-change disease
  • Nephrotic syndrome
  • Outcomes
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Long-term outcomes of childhood onset nephrotic syndrome. / Hjorten, Rebecca; Anwar, Zohra; Reidy, Kimberly J.

In: Frontiers in Pediatrics, Vol. 4, No. MAY, 53, 01.05.2016.

Research output: Contribution to journalShort survey

@article{74a37397755c43029d1830ff6813fdb0,
title = "Long-term outcomes of childhood onset nephrotic syndrome",
abstract = "There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.",
keywords = "Children, Focal glomerulosclerosis, Genetics, Minimal-change disease, Nephrotic syndrome, Outcomes, Pediatric",
author = "Rebecca Hjorten and Zohra Anwar and Reidy, {Kimberly J.}",
year = "2016",
month = "5",
day = "1",
doi = "10.3389/fped.2016.00053",
language = "English (US)",
volume = "4",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media S. A.",
number = "MAY",

}

TY - JOUR

T1 - Long-term outcomes of childhood onset nephrotic syndrome

AU - Hjorten, Rebecca

AU - Anwar, Zohra

AU - Reidy, Kimberly J.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

AB - There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

KW - Children

KW - Focal glomerulosclerosis

KW - Genetics

KW - Minimal-change disease

KW - Nephrotic syndrome

KW - Outcomes

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=85030213340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030213340&partnerID=8YFLogxK

U2 - 10.3389/fped.2016.00053

DO - 10.3389/fped.2016.00053

M3 - Short survey

VL - 4

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

SN - 2296-2360

IS - MAY

M1 - 53

ER -