Long-term outcomes of childhood onset nephrotic syndrome

Rebecca Hjorten, Zohra Anwar, Kimberly J. Reidy

Research output: Contribution to journalShort survey

9 Scopus citations

Abstract

There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

Original languageEnglish (US)
Article number53
JournalFrontiers in Pediatrics
Volume4
Issue numberMAY
DOIs
Publication statusPublished - May 1 2016

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Keywords

  • Children
  • Focal glomerulosclerosis
  • Genetics
  • Minimal-change disease
  • Nephrotic syndrome
  • Outcomes
  • Pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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