TY - JOUR
T1 - Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation
AU - Patel, Dimpi
AU - Bailey, Shane M.
AU - Furlan, Anthony J.
AU - Ching, Marilou
AU - Zachaib, Johathan
AU - Di Biase, Luigi
AU - Mohanty, Prasant
AU - Horton, Rodney P.
AU - Burkhardt, J. David
AU - Sanchez, Javier E.
AU - Zagrodzky, Jasin D.
AU - Gallinghouse, G. Joseph
AU - Schweikert, Robert
AU - Saliba, Walid
AU - Natale, Andrea
PY - 2010/4
Y1 - 2010/4
N2 - PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8%) (61 ± 8 years, 88% males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26%), left anterior circulation-5 patients (26%), posterior circulation-3 patients (16%), and 2 or more territories-6 patients (32%), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)
AB - PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8%) (61 ± 8 years, 88% males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26%), left anterior circulation-5 patients (26%), posterior circulation-3 patients (16%), and 2 or more territories-6 patients (32%), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)
KW - Atrial fibrillation
KW - Catheter ablation
KW - Cerebral thromboembolic event
KW - Pulmonary vein isolation
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=77950277786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950277786&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8167.2009.01650.x
DO - 10.1111/j.1540-8167.2009.01650.x
M3 - Article
C2 - 19925610
AN - SCOPUS:77950277786
SN - 1045-3873
VL - 21
SP - 412
EP - 417
JO - Journal of cardiovascular electrophysiology
JF - Journal of cardiovascular electrophysiology
IS - 4
ER -