Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation

Dimpi Patel, Shane M. Bailey, Anthony J. Furlan, Marilou Ching, Johathan Zachaib, Luigi Di Biase, Prasant Mohanty, Rodney P. Horton, J. David Burkhardt, Javier E. Sanchez, Jasin D. Zagrodzky, G. Joseph Gallinghouse, Robert Schweikert, Walid Saliba, Andrea Natale

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8%) (61 ± 8 years, 88% males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26%), left anterior circulation-5 patients (26%), posterior circulation-3 patients (16%), and 2 or more territories-6 patients (32%), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume21
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

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Catheter Ablation
Atrial Fibrillation
Pulmonary Veins
Stroke
International Normalized Ratio
Blood Vessels

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Cerebral thromboembolic event
  • Pulmonary vein isolation
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation. / Patel, Dimpi; Bailey, Shane M.; Furlan, Anthony J.; Ching, Marilou; Zachaib, Johathan; Di Biase, Luigi; Mohanty, Prasant; Horton, Rodney P.; Burkhardt, J. David; Sanchez, Javier E.; Zagrodzky, Jasin D.; Gallinghouse, G. Joseph; Schweikert, Robert; Saliba, Walid; Natale, Andrea.

In: Journal of Cardiovascular Electrophysiology, Vol. 21, No. 4, 2010, p. 412-417.

Research output: Contribution to journalArticle

Patel, D, Bailey, SM, Furlan, AJ, Ching, M, Zachaib, J, Di Biase, L, Mohanty, P, Horton, RP, Burkhardt, JD, Sanchez, JE, Zagrodzky, JD, Gallinghouse, GJ, Schweikert, R, Saliba, W & Natale, A 2010, 'Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation', Journal of Cardiovascular Electrophysiology, vol. 21, no. 4, pp. 412-417. https://doi.org/10.1111/j.1540-8167.2009.01650.x
Patel, Dimpi ; Bailey, Shane M. ; Furlan, Anthony J. ; Ching, Marilou ; Zachaib, Johathan ; Di Biase, Luigi ; Mohanty, Prasant ; Horton, Rodney P. ; Burkhardt, J. David ; Sanchez, Javier E. ; Zagrodzky, Jasin D. ; Gallinghouse, G. Joseph ; Schweikert, Robert ; Saliba, Walid ; Natale, Andrea. / Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation. In: Journal of Cardiovascular Electrophysiology. 2010 ; Vol. 21, No. 4. pp. 412-417.
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abstract = "PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8{\%}) (61 ± 8 years, 88{\%} males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26{\%}), left anterior circulation-5 patients (26{\%}), posterior circulation-3 patients (16{\%}), and 2 or more territories-6 patients (32{\%}), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)",
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T1 - Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation

AU - Patel, Dimpi

AU - Bailey, Shane M.

AU - Furlan, Anthony J.

AU - Ching, Marilou

AU - Zachaib, Johathan

AU - Di Biase, Luigi

AU - Mohanty, Prasant

AU - Horton, Rodney P.

AU - Burkhardt, J. David

AU - Sanchez, Javier E.

AU - Zagrodzky, Jasin D.

AU - Gallinghouse, G. Joseph

AU - Schweikert, Robert

AU - Saliba, Walid

AU - Natale, Andrea

PY - 2010

Y1 - 2010

N2 - PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8%) (61 ± 8 years, 88% males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26%), left anterior circulation-5 patients (26%), posterior circulation-3 patients (16%), and 2 or more territories-6 patients (32%), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)

AB - PVAI and Stroke. Introduction: Cerebral thromboembolic event (CTE) is a possible complication of pulmonary vein antrum isolation (PVAI). The objective of this study was to report long-term functional and neurocognitive recovery in patients who had a CTE during or within 48 hours of catheter ablation. Methods and Results: We screened 3,060 patients who underwent PVAI between January 2000 and June 2007. Out the 3,060 patients, 26 patients (0.8%) (61 ± 8 years, 88% males) had a CTE during or within 48 hours of the procedure. We followed these 26 patients (study group) over time and assessed their functional and neurocognitive recovery status. No preferential vascular territory for the site of obstruction was found; right anterior circulation-5 patients (26%), left anterior circulation-5 patients (26%), posterior circulation-3 patients (16%), and 2 or more territories-6 patients (32%), (P-value = 0.8). The average international normalized ratio at the time of CTE was 1.33 ± 0.4. Two patients died during the study period. At the end of 38.4 ± 24 months follow-up, most surviving patients had complete neurocognitive and functional recovery irrespective of the severity of periprocedural stroke. Conclusions: Periprocedural stroke in the setting of catheter ablation for atrial fibrillation is relatively rare. When it occurs, complete functional and neurocognitive recovery over time is the likely outcome for most patients. (J Cardiovasc Electrophysiol, Vol. 21, pp. 412-417, April 2010)

KW - Atrial fibrillation

KW - Catheter ablation

KW - Cerebral thromboembolic event

KW - Pulmonary vein isolation

KW - Stroke

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