Long-term alcohol and caffeine intake and risk of sudden cardiac death in women

Monica L. Bertoia, Elizabeth W. Triche, Dominique S. Michaud, Ana Baylin, Joseph W. Hogan, Marian L. Neuhouser, Matthew S. Freiberg, Matthew A. Allison, Monika M. Safford, Wenjun Li, Yasmin Mossavar-Rahmani, Milagros C. Rosal, Charles B. Eaton

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Alcohol and caffeine intakes may play a role in the development of sudden cardiac death (SCD) because of their effects on cholesterol, blood pressure, heart rate variability, and inflammation. Objective: Our objective was to examine the association between long-term alcohol and caffeine intakes and risk of SCD in women. Design: We examined 93,676 postmenopausal women who participated in the Women's Health Initiative Observational Study. Women were enrolled between 1993 and 1998 and were followed until August 2009. Women completed a food-frequency questionnaire at baseline and again at year 3. We modeled exposure to alcohol 3 ways: by using baseline intake only, a cumulative average of baseline and year 3 intake, and the most recent reported intake (a simple time-varying analysis). Results: Intake of 5-15 g alcohol/d (about one drink) was associated with a nonsignificantly reduced risk of SCD compared with 0.1-5 g/d of baseline intake (HR: 0.64; 95% CI: 0.40, 1.02), of cumulative average intake (HR: 0.69; 95% CI: 0.43, 1.11), and of most recent intake (HR: 0.58; 95% CI: 0.35, 0.96), with adjustment for age, race, income, smoking, body mass index, physical activity, hormone use, and total energy. No association was found between SCD and total caffeine intake (mg/d) or cups of caffeinated coffee, decaffeinated coffee, and caffeinated tea. Conclusions: Our results suggest that about one drink per day (or 5.1-15 g/d) may be associated with a reduced risk of SCD in this population; however, this association was only statistically significant for a model using the most recent alcohol intake. Total caffeine, regular coffee, decaffeinated coffee, and regular tea intake were not associated with the risk of SCD. This trial was registered at clinicaltrials.gov as NCT00000611.

Original languageEnglish (US)
Pages (from-to)1356-1363
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume97
Issue number6
DOIs
StatePublished - Jun 1 2013

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Sudden Cardiac Death
Caffeine
Coffee
Alcohols
Tea
Women's Health
Observational Studies
Body Mass Index
Heart Rate
Smoking
Cholesterol
Hormones
Exercise
Blood Pressure
Inflammation
Food
Population

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bertoia, M. L., Triche, E. W., Michaud, D. S., Baylin, A., Hogan, J. W., Neuhouser, M. L., ... Eaton, C. B. (2013). Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. American Journal of Clinical Nutrition, 97(6), 1356-1363. https://doi.org/10.3945/ajcn.112.044248

Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. / Bertoia, Monica L.; Triche, Elizabeth W.; Michaud, Dominique S.; Baylin, Ana; Hogan, Joseph W.; Neuhouser, Marian L.; Freiberg, Matthew S.; Allison, Matthew A.; Safford, Monika M.; Li, Wenjun; Mossavar-Rahmani, Yasmin; Rosal, Milagros C.; Eaton, Charles B.

In: American Journal of Clinical Nutrition, Vol. 97, No. 6, 01.06.2013, p. 1356-1363.

Research output: Contribution to journalArticle

Bertoia, ML, Triche, EW, Michaud, DS, Baylin, A, Hogan, JW, Neuhouser, ML, Freiberg, MS, Allison, MA, Safford, MM, Li, W, Mossavar-Rahmani, Y, Rosal, MC & Eaton, CB 2013, 'Long-term alcohol and caffeine intake and risk of sudden cardiac death in women', American Journal of Clinical Nutrition, vol. 97, no. 6, pp. 1356-1363. https://doi.org/10.3945/ajcn.112.044248
Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW, Neuhouser ML et al. Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. American Journal of Clinical Nutrition. 2013 Jun 1;97(6):1356-1363. https://doi.org/10.3945/ajcn.112.044248
Bertoia, Monica L. ; Triche, Elizabeth W. ; Michaud, Dominique S. ; Baylin, Ana ; Hogan, Joseph W. ; Neuhouser, Marian L. ; Freiberg, Matthew S. ; Allison, Matthew A. ; Safford, Monika M. ; Li, Wenjun ; Mossavar-Rahmani, Yasmin ; Rosal, Milagros C. ; Eaton, Charles B. / Long-term alcohol and caffeine intake and risk of sudden cardiac death in women. In: American Journal of Clinical Nutrition. 2013 ; Vol. 97, No. 6. pp. 1356-1363.
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