Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33‐qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33‐qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki‐ I lymphomas.
ASJC Scopus subject areas
- Cancer Research