Localization and activity of nitric oxide synthases in the gastrointestinal tract of Trypanosoma cruzi-infected mice

L. Ny, K. Persson, B. Larsson, J. Chan, L. M. Weiss, M. Wittner, H. Huang, H. B. Tanowitz

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Chagas' disease, caused by the protozoan parasite, Trypanosoma cruzi, is associated with gastrointestinal abnormalities. Since nitric oxide (NO) has been shown to be a factor influencing intestinal function we evaluated the distributions and activities of the NO synthase (NOS) isoforms, in the gut of mice infected with T. cruzi. Ca2+-dependent (NOS1/NOS3) activity was decreased, whereas Ca2+-independent (NOS2) activity was increased in infected mice. NOS2-immunoreactivity was demonstrated in cells within the muscle layers and epithelium in infected mice and NOS1 immunoreactivity was seen in nerve structures. These data indicate that alterations in the NO- system may be important in the pathogenesis of the gastrointestinal manifestations in Chagas' disease.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalJournal of Neuroimmunology
Volume99
Issue number1
DOIs
StatePublished - Sep 1 1999

Keywords

  • Chagas' disease
  • Enteric nervous system
  • Intestine
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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