Lithium does not inhibit the parathyroid hormone mediated rise in urinary cyclic AMP and phosphate in humans

Allen M. Spiegel, R. H. Gerner, D. L. Murphy, G. D. Aurbach

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To test the hypothesis that lithium is a general inhibitor of hormone activated adenylate cyclase, the authors infused parathyroid hormone (PTH) into human subjects prior to and during lithium carbonate administration. PTH infusion caused a significant increase in urinary cyclic AMP and urinary phosphate excretion. There was no significant difference in these responses in the lithium compared to the control period. In 4 patients with primary hyperparathyroidism, lithium had no significant effect on serum calcium or phosphate or on tubular reabsorption of phosphate. The data do not substantiate the hypothesis that lithium (at therapeutic concentrations) is a general inhibitor of hormonally activated adenylate cyclase, nor do they support its potential clinical utility in primary hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)1390-1393
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number6
StatePublished - 1976
Externally publishedYes

Fingerprint

Parathyroid Hormone
Lithium
Cyclic AMP
Phosphates
Primary Hyperparathyroidism
Adenylyl Cyclases
Lithium Carbonate
Hormones
Calcium
Serum
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lithium does not inhibit the parathyroid hormone mediated rise in urinary cyclic AMP and phosphate in humans. / Spiegel, Allen M.; Gerner, R. H.; Murphy, D. L.; Aurbach, G. D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 6, 1976, p. 1390-1393.

Research output: Contribution to journalArticle

@article{b20be654bc0e4410a06d455dfba727cf,
title = "Lithium does not inhibit the parathyroid hormone mediated rise in urinary cyclic AMP and phosphate in humans",
abstract = "To test the hypothesis that lithium is a general inhibitor of hormone activated adenylate cyclase, the authors infused parathyroid hormone (PTH) into human subjects prior to and during lithium carbonate administration. PTH infusion caused a significant increase in urinary cyclic AMP and urinary phosphate excretion. There was no significant difference in these responses in the lithium compared to the control period. In 4 patients with primary hyperparathyroidism, lithium had no significant effect on serum calcium or phosphate or on tubular reabsorption of phosphate. The data do not substantiate the hypothesis that lithium (at therapeutic concentrations) is a general inhibitor of hormonally activated adenylate cyclase, nor do they support its potential clinical utility in primary hyperparathyroidism.",
author = "Spiegel, {Allen M.} and Gerner, {R. H.} and Murphy, {D. L.} and Aurbach, {G. D.}",
year = "1976",
language = "English (US)",
volume = "43",
pages = "1390--1393",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "6",

}

TY - JOUR

T1 - Lithium does not inhibit the parathyroid hormone mediated rise in urinary cyclic AMP and phosphate in humans

AU - Spiegel, Allen M.

AU - Gerner, R. H.

AU - Murphy, D. L.

AU - Aurbach, G. D.

PY - 1976

Y1 - 1976

N2 - To test the hypothesis that lithium is a general inhibitor of hormone activated adenylate cyclase, the authors infused parathyroid hormone (PTH) into human subjects prior to and during lithium carbonate administration. PTH infusion caused a significant increase in urinary cyclic AMP and urinary phosphate excretion. There was no significant difference in these responses in the lithium compared to the control period. In 4 patients with primary hyperparathyroidism, lithium had no significant effect on serum calcium or phosphate or on tubular reabsorption of phosphate. The data do not substantiate the hypothesis that lithium (at therapeutic concentrations) is a general inhibitor of hormonally activated adenylate cyclase, nor do they support its potential clinical utility in primary hyperparathyroidism.

AB - To test the hypothesis that lithium is a general inhibitor of hormone activated adenylate cyclase, the authors infused parathyroid hormone (PTH) into human subjects prior to and during lithium carbonate administration. PTH infusion caused a significant increase in urinary cyclic AMP and urinary phosphate excretion. There was no significant difference in these responses in the lithium compared to the control period. In 4 patients with primary hyperparathyroidism, lithium had no significant effect on serum calcium or phosphate or on tubular reabsorption of phosphate. The data do not substantiate the hypothesis that lithium (at therapeutic concentrations) is a general inhibitor of hormonally activated adenylate cyclase, nor do they support its potential clinical utility in primary hyperparathyroidism.

UR - http://www.scopus.com/inward/record.url?scp=0017055502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017055502&partnerID=8YFLogxK

M3 - Article

C2 - 187615

AN - SCOPUS:0017055502

VL - 43

SP - 1390

EP - 1393

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -