Lithium and valproate treatment of pathological gambling: A randomized single-blind study

Stefano Pallanti, Leonardo Quercioli, Erica Sood, Eric Hollander

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Objective: The aim of the present study was to evaluate the efficacy and safety of lithium and valproate in nonbipolar pathological gamblers. Method: Forty-two subjects with DSM-IV-defined pathological gambling entered a 14-week single-blind trial with lithium (N = 23) or valproate (N = 19). A total of 15 subjects on lithium treatment and 16 patients on valproate treatment completed the 14-week protocol. Results: At the end of the 14-week treatment period, both the lithium and the valproate groups showed significant (p < .01) improvement in mean score on the Yale-Brown Obsessive Compulsive Scale modified for pathological gambling. This improvement did not significantly differ between groups. Fourteen (60.9%) of the 23 patients taking lithium and 13 (68.4%) of the 19 patients taking valproate were responders based on a Clinical Global Impressions-Improvement score of much or very much improved. Conclusion: Findings from the present study suggest the efficacy of both lithium carbonate and valproate in the treatment of pathological gambling. This is the first controlled trial of the efficacy of mood stabilizers in pathological gambling. A double-blind, placebo-controlled trial is required to confirm these findings.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalJournal of Clinical Psychiatry
Volume63
Issue number7
StatePublished - 2002
Externally publishedYes

Fingerprint

Single-Blind Method
Gambling
Valproic Acid
Lithium
Therapeutics
Lithium Carbonate
Diagnostic and Statistical Manual of Mental Disorders
Placebos
Safety

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Lithium and valproate treatment of pathological gambling : A randomized single-blind study. / Pallanti, Stefano; Quercioli, Leonardo; Sood, Erica; Hollander, Eric.

In: Journal of Clinical Psychiatry, Vol. 63, No. 7, 2002, p. 559-564.

Research output: Contribution to journalArticle

Pallanti, Stefano ; Quercioli, Leonardo ; Sood, Erica ; Hollander, Eric. / Lithium and valproate treatment of pathological gambling : A randomized single-blind study. In: Journal of Clinical Psychiatry. 2002 ; Vol. 63, No. 7. pp. 559-564.
@article{8c412191a07c4f50801ca35bb04c2a2c,
title = "Lithium and valproate treatment of pathological gambling: A randomized single-blind study",
abstract = "Objective: The aim of the present study was to evaluate the efficacy and safety of lithium and valproate in nonbipolar pathological gamblers. Method: Forty-two subjects with DSM-IV-defined pathological gambling entered a 14-week single-blind trial with lithium (N = 23) or valproate (N = 19). A total of 15 subjects on lithium treatment and 16 patients on valproate treatment completed the 14-week protocol. Results: At the end of the 14-week treatment period, both the lithium and the valproate groups showed significant (p < .01) improvement in mean score on the Yale-Brown Obsessive Compulsive Scale modified for pathological gambling. This improvement did not significantly differ between groups. Fourteen (60.9{\%}) of the 23 patients taking lithium and 13 (68.4{\%}) of the 19 patients taking valproate were responders based on a Clinical Global Impressions-Improvement score of much or very much improved. Conclusion: Findings from the present study suggest the efficacy of both lithium carbonate and valproate in the treatment of pathological gambling. This is the first controlled trial of the efficacy of mood stabilizers in pathological gambling. A double-blind, placebo-controlled trial is required to confirm these findings.",
author = "Stefano Pallanti and Leonardo Quercioli and Erica Sood and Eric Hollander",
year = "2002",
language = "English (US)",
volume = "63",
pages = "559--564",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "7",

}

TY - JOUR

T1 - Lithium and valproate treatment of pathological gambling

T2 - A randomized single-blind study

AU - Pallanti, Stefano

AU - Quercioli, Leonardo

AU - Sood, Erica

AU - Hollander, Eric

PY - 2002

Y1 - 2002

N2 - Objective: The aim of the present study was to evaluate the efficacy and safety of lithium and valproate in nonbipolar pathological gamblers. Method: Forty-two subjects with DSM-IV-defined pathological gambling entered a 14-week single-blind trial with lithium (N = 23) or valproate (N = 19). A total of 15 subjects on lithium treatment and 16 patients on valproate treatment completed the 14-week protocol. Results: At the end of the 14-week treatment period, both the lithium and the valproate groups showed significant (p < .01) improvement in mean score on the Yale-Brown Obsessive Compulsive Scale modified for pathological gambling. This improvement did not significantly differ between groups. Fourteen (60.9%) of the 23 patients taking lithium and 13 (68.4%) of the 19 patients taking valproate were responders based on a Clinical Global Impressions-Improvement score of much or very much improved. Conclusion: Findings from the present study suggest the efficacy of both lithium carbonate and valproate in the treatment of pathological gambling. This is the first controlled trial of the efficacy of mood stabilizers in pathological gambling. A double-blind, placebo-controlled trial is required to confirm these findings.

AB - Objective: The aim of the present study was to evaluate the efficacy and safety of lithium and valproate in nonbipolar pathological gamblers. Method: Forty-two subjects with DSM-IV-defined pathological gambling entered a 14-week single-blind trial with lithium (N = 23) or valproate (N = 19). A total of 15 subjects on lithium treatment and 16 patients on valproate treatment completed the 14-week protocol. Results: At the end of the 14-week treatment period, both the lithium and the valproate groups showed significant (p < .01) improvement in mean score on the Yale-Brown Obsessive Compulsive Scale modified for pathological gambling. This improvement did not significantly differ between groups. Fourteen (60.9%) of the 23 patients taking lithium and 13 (68.4%) of the 19 patients taking valproate were responders based on a Clinical Global Impressions-Improvement score of much or very much improved. Conclusion: Findings from the present study suggest the efficacy of both lithium carbonate and valproate in the treatment of pathological gambling. This is the first controlled trial of the efficacy of mood stabilizers in pathological gambling. A double-blind, placebo-controlled trial is required to confirm these findings.

UR - http://www.scopus.com/inward/record.url?scp=0036077324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036077324&partnerID=8YFLogxK

M3 - Article

C2 - 12143910

AN - SCOPUS:0036077324

VL - 63

SP - 559

EP - 564

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 7

ER -