Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

Noa Schwartz, Jennifer S. Michaelson, Chaim Putterman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

46 Scopus citations

Abstract

Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.

Original languageEnglish (US)
Title of host publicationAutoimmunity, Part A Basic Principles and New Diagnostic Tools
PublisherBlackwell Publishing Inc.
Pages265-274
Number of pages10
ISBN (Print)1573316636, 9781573316637
DOIs
StatePublished - Aug 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1109
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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Keywords

  • Biomarkers
  • Lipocalin-2
  • Lupus nephritis
  • Systemic lupus erythematosus
  • TWEAK

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Schwartz, N., Michaelson, J. S., & Putterman, C. (2007). Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. In Autoimmunity, Part A Basic Principles and New Diagnostic Tools (pp. 265-274). (Annals of the New York Academy of Sciences; Vol. 1109). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1398.032