Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

Noa Schwartz, Jennifer S. Michaelson, Chaim Putterman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

45 Citations (Scopus)

Abstract

Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages265-274
Number of pages10
Volume1109
DOIs
StatePublished - Aug 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1109
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Lipocalins
Lupus Nephritis
Biomarkers
Cytokines
Kidney
Interleukin-8
Systemic Lupus Erythematosus
Interleukin-6
Morbidity
Mortality
Lipocalin-2

Keywords

  • Biomarkers
  • Lipocalin-2
  • Lupus nephritis
  • Systemic lupus erythematosus
  • TWEAK

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Schwartz, N., Michaelson, J. S., & Putterman, C. (2007). Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. In Annals of the New York Academy of Sciences (Vol. 1109, pp. 265-274). (Annals of the New York Academy of Sciences; Vol. 1109). https://doi.org/10.1196/annals.1398.032

Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. / Schwartz, Noa; Michaelson, Jennifer S.; Putterman, Chaim.

Annals of the New York Academy of Sciences. Vol. 1109 2007. p. 265-274 (Annals of the New York Academy of Sciences; Vol. 1109).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Schwartz, N, Michaelson, JS & Putterman, C 2007, Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. in Annals of the New York Academy of Sciences. vol. 1109, Annals of the New York Academy of Sciences, vol. 1109, pp. 265-274. https://doi.org/10.1196/annals.1398.032
Schwartz N, Michaelson JS, Putterman C. Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. In Annals of the New York Academy of Sciences. Vol. 1109. 2007. p. 265-274. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1398.032
Schwartz, Noa ; Michaelson, Jennifer S. ; Putterman, Chaim. / Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. Annals of the New York Academy of Sciences. Vol. 1109 2007. pp. 265-274 (Annals of the New York Academy of Sciences).
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