Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

Noa Schwartz; Jennifer S. Michaelson; Chaim Putterman

doi:10.1196/annals.1398.032

Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

Noa Schwartz, Jennifer S. Michaelson, Chaim Putterman

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

58 Scopus citations

Abstract

Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.

Original language	English (US)
Title of host publication	Autoimmunity, Part A Basic Principles and New Diagnostic Tools
Publisher	Blackwell Publishing Inc.
Pages	265-274
Number of pages	10
ISBN (Print)	1573316636, 9781573316637
DOIs	https://doi.org/10.1196/annals.1398.032
State	Published - Aug 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1109
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Biomarkers
Lipocalin-2
Lupus nephritis
Systemic lupus erythematosus
TWEAK

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1398.032

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Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis. / Schwartz, Noa; Michaelson, Jennifer S.; Putterman, Chaim.
Autoimmunity, Part A Basic Principles and New Diagnostic Tools. Blackwell Publishing Inc., 2007. p. 265-274 (Annals of the New York Academy of Sciences; Vol. 1109).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.",

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N2 - Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.

AB - Lupus nephritis (LN) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). As the course of LN is often unpredictable, it is important to identify reliable, noninvasive methods to repeatedly assess the condition of the kidneys in these patients. Urinary biomarkers are easily obtained and probably are best at reflecting the current renal status, as they specifically represent local inflammatory activity. In this article, we review a number of potential urinary biomarkers, including Lipocalin-2, MCP-1, IP-10, IL-6, and IL-8. Additionally, we provide evidence for the possible utility of the novel cytokine TWEAK as a urinary biomarker for LN.

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Lipocalin-2, TWEAK, and other cytokines as urinary biomarkers for lupus nephritis

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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