Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages

J. Chan, X. Fan, S. W. Hunter, P. J. Brennan, B. R. Bloom

Research output: Contribution to journalArticle

303 Scopus citations

Abstract

Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of tuberculosis and leprosy, respectively, produce large quantities of lipoarabinomannan (LAM), a highly immunogenic, cell wall-associated glycolipid. This molecule has been previously reported to be a potent inhibitor of gamma interferon-mediated activation of murine macrophages. Studies of the mechanism by which this mycobacterial glycolipid down-regulates macrophage effector functions provide evidence that LAM acts at several levels and that it can (i) scavenge potentially cytotoxic oxygen free radicals, (ii) inhibit protein kinase C activity, and (iii) block the transcriptional activation of gamma interferon-inducible genes in human macrophage-like cell lines. These results suggest that LAM can inhibit macrophage activation and triggering and cytocidal activity and that it may represent a chemically defined virulence factor contributing to the persistence of mycobacteria within mononuclear phagocytes.

Original languageEnglish (US)
Pages (from-to)1755-1761
Number of pages7
JournalInfection and immunity
Volume59
Issue number5
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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