Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages

John Chan, X. Fan, S. W. Hunter, P. J. Brennan, B. R. Bloom

Research output: Contribution to journalArticle

297 Citations (Scopus)

Abstract

Mycobacterium tuberculosis and Mycobacterium leprae, the causative agents of tuberculosis and leprosy, respectively, produce large quantities of lipoarabinomannan (LAM), a highly immunogenic, cell wall-associated glycolipid. This molecule has been previously reported to be a potent inhibitor of gamma interferon-mediated activation of murine macrophages. Studies of the mechanism by which this mycobacterial glycolipid down-regulates macrophage effector functions provide evidence that LAM acts at several levels and that it can (i) scavenge potentially cytotoxic oxygen free radicals, (ii) inhibit protein kinase C activity, and (iii) block the transcriptional activation of gamma interferon-inducible genes in human macrophage-like cell lines. These results suggest that LAM can inhibit macrophage activation and triggering and cytocidal activity and that it may represent a chemically defined virulence factor contributing to the persistence of mycobacteria within mononuclear phagocytes.

Original languageEnglish (US)
Pages (from-to)1755-1761
Number of pages7
JournalInfection and Immunity
Volume59
Issue number5
StatePublished - 1991

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Virulence Factors
Mycobacterium tuberculosis
Macrophage Activation
Glycolipids
Macrophages
Interferon-gamma
Mycobacterium leprae
Leprosy
Mycobacterium
Phagocytes
Cell Wall
Protein Kinase C
Transcriptional Activation
Free Radicals
Reactive Oxygen Species
Tuberculosis
Down-Regulation
Cell Line
Genes
lipoarabinomannan

ASJC Scopus subject areas

  • Immunology

Cite this

Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. / Chan, John; Fan, X.; Hunter, S. W.; Brennan, P. J.; Bloom, B. R.

In: Infection and Immunity, Vol. 59, No. 5, 1991, p. 1755-1761.

Research output: Contribution to journalArticle

Chan, John ; Fan, X. ; Hunter, S. W. ; Brennan, P. J. ; Bloom, B. R. / Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. In: Infection and Immunity. 1991 ; Vol. 59, No. 5. pp. 1755-1761.
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