Lipidomic Signatures of Dairy Consumption and Associated Changes in Blood Pressure and Other Cardiovascular Risk Factors among Chinese Adults

Huan Yun, Liang Sun, Qingqing Wu, Yaogan Luo, Qibin Qi, Huaixing Li, Weiqiong Gu, Jiqiu Wang, Guang Ning, Rong Zeng, Geng Zong, Xu Lin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health. Methods: Dairy-related lipidomic signatures were discovered in baseline data from a Chinese cohort study (n=2140) and replicated in another Chinese study (n=212). Dairy intake was estimated by a validated food-frequency questionnaire. Lipidomics was profiled by high-coverage liquid chromatography-tandem mass spectrometry. Associations of dairy-related lipids with 6-year changes in cardiovascular risk factors were examined in the discovery cohort, and their causalities were analyzed by 2-sample Mendelian randomization using available genome-wide summary data. Results: Of 350 lipid metabolites, 4 sphingomyelins, namely sphingomyelin (OH) C32:2, sphingomyelin C32:1, sphingomyelin (2OH) C30:2, and sphingomyelin (OH) C38:2, were identified and replicated to be positively associated with total dairy consumption (β=0.130 to 0.148; P<1.43×10-4), but not or weakly with nondairy food items. The score of 4 sphingomyelins showed inverse associations with 6-year changes in systolic (-2.68 [95% CI, -4.92 to -0.43]; P=0.019), diastolic blood pressures (-1.86 [95% CI, -3.12 to -0.61]; P=0.004), and fasting glucose (-0.25 [95% CI, -0.41 to -0.08]; P=0.003). Mendelian randomization analyses further revealed that genetically inferred sphingomyelin (OH) C32:2 was inversely associated with systolic (-0.57 [95% CI, -0.85 to -0.28]; P=9.16×10-5) and diastolic blood pressures (-0.39 [95% CI, -0.59 to -0.20]; P=7.09×10-5). Conclusions: The beneficial effects of dairy products on cardiovascular health might be mediated through specific sphingomyelins among Chinese with overall low dairy consumption.

Original languageEnglish (US)
Pages (from-to)1617-1628
Number of pages12
JournalHypertension
Volume79
Issue number8
DOIs
StatePublished - Aug 1 2022

Keywords

  • blood pressure
  • dairy
  • hypertension
  • lipidomics
  • sphingomyelins

ASJC Scopus subject areas

  • Internal Medicine

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