LINAC radiosurgery: An animal model

R. Spiegelmann, W. A. Friedman, F. J. Bova, D. P. Theele, J. P. Mickle

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium- enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the higher-dose lesions contained increasing amounts of hemorrhage and coagulative necrosis. The borders of the lesions were sharply demarcated from surrounding normal brain. Gadolinium-enhanced MR studies correlated well with areas of blood-brain barrier breakdown, as confirmed by areas of Evans blue staining. This model could serve as the basis for further studies of the biological effects of LINAC radiosurgery.

Original languageEnglish (US)
Pages (from-to)638-644
Number of pages7
JournalJournal of neurosurgery
Issue number4
StatePublished - Jan 1 1993


  • cat
  • linear accelerator
  • radiation necrosis
  • radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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