Abstract
Fifteen cats were irradiated with an animal LINAC (linear accelerator) radiosurgery device. After 6 months, they were studied with gadolinium- enhanced magnetic resonance (MR) imaging, gross pathology after Evans blue perfusion, and histopathology. The lesion size was relatively constant in the cats receiving a dose of 7500, 10,000, 12,500, or 15,000 cGy to the 84% isodose line of a 1-cm collimator. The composition of the lesion correlated with dose: the lower-dose lesions were found histologically to contain areas of edema, demyelination, reactive gliosis, and vascular proliferation; the higher-dose lesions contained increasing amounts of hemorrhage and coagulative necrosis. The borders of the lesions were sharply demarcated from surrounding normal brain. Gadolinium-enhanced MR studies correlated well with areas of blood-brain barrier breakdown, as confirmed by areas of Evans blue staining. This model could serve as the basis for further studies of the biological effects of LINAC radiosurgery.
Original language | English (US) |
---|---|
Pages (from-to) | 638-644 |
Number of pages | 7 |
Journal | Journal of neurosurgery |
Volume | 78 |
Issue number | 4 |
DOIs | |
State | Published - 1993 |
Externally published | Yes |
Keywords
- cat
- linear accelerator
- radiation necrosis
- radiosurgery
ASJC Scopus subject areas
- Surgery
- Clinical Neurology