Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Nina Balthasar, Roberto Coppari, Julie McMinn, Shun M. Liu, Charlotte E. Lee, Vinsee Tang, Christopher D. Kenny, Robert A. McGovern, Streamson C. Chua, Joel K. Elmquist, Bradford B. Lowell

Research output: Contribution to journalArticle

627 Scopus citations


Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here, using the Cre/loxP system, we critically test the functional importance of leptin action on POMC neurons by deleting leptin receptors specifically from these cells in mice. Mice lacking leptin signaling in POMC neurons are mildly obese, hyperleptinemic, and have altered expression of hypothalamic neuropeptides. In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis.

Original languageEnglish (US)
Pages (from-to)983-991
Number of pages9
Issue number6
StatePublished - Jun 24 2004


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., & Lowell, B. B. (2004). Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron, 42(6), 983-991. https://doi.org/10.1016/j.neuron.2004.06.004