Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Nina Balthasar, Roberto Coppari, Julie McMinn, Shun M. Liu, Charlotte E. Lee, Vinsee Tang, Christopher D. Kenny, Robert A. McGovern, Streamson C. Chua, Jr., Joel K. Elmquist, Bradford B. Lowell

Research output: Contribution to journalArticle

605 Citations (Scopus)

Abstract

Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here, using the Cre/loxP system, we critically test the functional importance of leptin action on POMC neurons by deleting leptin receptors specifically from these cells in mice. Mice lacking leptin signaling in POMC neurons are mildly obese, hyperleptinemic, and have altered expression of hypothalamic neuropeptides. In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis.

Original languageEnglish (US)
Pages (from-to)983-991
Number of pages9
JournalNeuron
Volume42
Issue number6
DOIs
StatePublished - Jun 24 2004
Externally publishedYes

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Leptin Receptors
Ideal Body Weight
Pro-Opiomelanocortin
Leptin
Homeostasis
Neurons
Neuropeptides
Body Weight
Hormones

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., ... Lowell, B. B. (2004). Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron, 42(6), 983-991. https://doi.org/10.1016/j.neuron.2004.06.004

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. / Balthasar, Nina; Coppari, Roberto; McMinn, Julie; Liu, Shun M.; Lee, Charlotte E.; Tang, Vinsee; Kenny, Christopher D.; McGovern, Robert A.; Chua, Jr., Streamson C.; Elmquist, Joel K.; Lowell, Bradford B.

In: Neuron, Vol. 42, No. 6, 24.06.2004, p. 983-991.

Research output: Contribution to journalArticle

Balthasar, N, Coppari, R, McMinn, J, Liu, SM, Lee, CE, Tang, V, Kenny, CD, McGovern, RA, Chua, Jr., SC, Elmquist, JK & Lowell, BB 2004, 'Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis', Neuron, vol. 42, no. 6, pp. 983-991. https://doi.org/10.1016/j.neuron.2004.06.004
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24;42(6):983-991. https://doi.org/10.1016/j.neuron.2004.06.004
Balthasar, Nina ; Coppari, Roberto ; McMinn, Julie ; Liu, Shun M. ; Lee, Charlotte E. ; Tang, Vinsee ; Kenny, Christopher D. ; McGovern, Robert A. ; Chua, Jr., Streamson C. ; Elmquist, Joel K. ; Lowell, Bradford B. / Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. In: Neuron. 2004 ; Vol. 42, No. 6. pp. 983-991.
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