Leadless pacing: Presente e Futuro della stimolazione cardiaca

Translated title of the contribution: Leadless pacing: Present and future of cardiac stimulation

Agostino Piro, Carlo Lavalle, Domenico G. Della Rocca, Paola Scarparo, Massimo Mancone, Viviana Maestrini, Luigi Di Biase, Andrea Natale, Francesco Fedele

Research output: Contribution to journalReview article


Leadless pacemaker therapy now represents a reality in the field of cardiac pacing. It was developed with the aim of reducing post-procedural complications due to endocavitary leads and with the intention to propose itself as a valid alternative in patients who have contraindications to conventional pacing. Leadless pacemakers to date allow right ventricular stimulation and are implanted through a percutaneous venous femoral access. Currently, the system available is the Micra TM Transcatheter Pacing System. On November 2017, the worldwide implants of the Nanostim TM Leadless Pacemaker System were halted. These devices have shown promising results in the various clinical trials with complications mostly due to the implant procedure. In order to avoid these complications, a correct learning curve of the operators has resulted very important. Recently, a new system, the WiSE-CRT, has been introduced as a leadless alternative to cardiac resynchronization therapy. While the results of randomized trials and long-term follow-up studies are still pending, in this paper we will review the main clinical data that have been published to date, comparing them to the traditional devices for transvenous endocardial stimulation.

Original languageItalian
Pages (from-to)32-40
Number of pages9
JournalGiornale Italiano di Cardiologia
Issue number1
StatePublished - Jan 2019



  • Bradyarrhythmias
  • Cardiac arrhythmias
  • Cardiac pacing
  • Cardiac resynchronization therapy
  • Leadless pacemaker
  • Transvenous leads
  • Transvenous pacemaker

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Piro, A., Lavalle, C., Della Rocca, D. G., Scarparo, P., Mancone, M., Maestrini, V., Biase, L. D., Natale, A., & Fedele, F. (2019). Leadless pacing: Presente e Futuro della stimolazione cardiaca. Giornale Italiano di Cardiologia, 20(1), 32-40. https://doi.org/10.1714/3079.30718