LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

Elena Tarabra, Paola Pazienza, Elisabetta Borghesio, Giovanni C. Actis, Gianfranco Tappero, Luciana Framarin, Mohammad Ayoubi, Francesca Castellino, Nicola Leone, Giovanni Sansoè, Paolo De Paolis, Alessandro Comandone, Floriano Rosina

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

Original languageEnglish (US)
Pages (from-to)741-743
Number of pages3
JournalDigestive and Liver Disease
Volume42
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

Fingerprint

Lactose Intolerance
Lactase
Italy
Colorectal Neoplasms
Polyps
Genotype
Population
Real-Time Polymerase Chain Reaction

Keywords

  • Colorectal cancer
  • Lactose intolerance
  • LCT-13910C>T
  • Polymorphism

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Tarabra, E., Pazienza, P., Borghesio, E., Actis, G. C., Tappero, G., Framarin, L., ... Rosina, F. (2010). LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy. Digestive and Liver Disease, 42(10), 741-743. https://doi.org/10.1016/j.dld.2010.02.013

LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy. / Tarabra, Elena; Pazienza, Paola; Borghesio, Elisabetta; Actis, Giovanni C.; Tappero, Gianfranco; Framarin, Luciana; Ayoubi, Mohammad; Castellino, Francesca; Leone, Nicola; Sansoè, Giovanni; De Paolis, Paolo; Comandone, Alessandro; Rosina, Floriano.

In: Digestive and Liver Disease, Vol. 42, No. 10, 10.2010, p. 741-743.

Research output: Contribution to journalArticle

Tarabra, E, Pazienza, P, Borghesio, E, Actis, GC, Tappero, G, Framarin, L, Ayoubi, M, Castellino, F, Leone, N, Sansoè, G, De Paolis, P, Comandone, A & Rosina, F 2010, 'LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy', Digestive and Liver Disease, vol. 42, no. 10, pp. 741-743. https://doi.org/10.1016/j.dld.2010.02.013
Tarabra, Elena ; Pazienza, Paola ; Borghesio, Elisabetta ; Actis, Giovanni C. ; Tappero, Gianfranco ; Framarin, Luciana ; Ayoubi, Mohammad ; Castellino, Francesca ; Leone, Nicola ; Sansoè, Giovanni ; De Paolis, Paolo ; Comandone, Alessandro ; Rosina, Floriano. / LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy. In: Digestive and Liver Disease. 2010 ; Vol. 42, No. 10. pp. 741-743.
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abstract = "Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95{\%} CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95{\%} CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60{\%} of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.",
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author = "Elena Tarabra and Paola Pazienza and Elisabetta Borghesio and Actis, {Giovanni C.} and Gianfranco Tappero and Luciana Framarin and Mohammad Ayoubi and Francesca Castellino and Nicola Leone and Giovanni Sanso{\`e} and {De Paolis}, Paolo and Alessandro Comandone and Floriano Rosina",
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AU - Pazienza, Paola

AU - Borghesio, Elisabetta

AU - Actis, Giovanni C.

AU - Tappero, Gianfranco

AU - Framarin, Luciana

AU - Ayoubi, Mohammad

AU - Castellino, Francesca

AU - Leone, Nicola

AU - Sansoè, Giovanni

AU - De Paolis, Paolo

AU - Comandone, Alessandro

AU - Rosina, Floriano

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AB - Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

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