LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

Elena Tarabra, Paola Pazienza, Elisabetta Borghesio, Giovanni C. Actis, Gianfranco Tappero, Luciana Framarin, Mohammad Ayoubi, Francesca Castellino, Nicola Leone, Giovanni Sansoè, Paolo De Paolis, Alessandro Comandone, Floriano Rosina

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

Original languageEnglish (US)
Pages (from-to)741-743
Number of pages3
JournalDigestive and Liver Disease
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

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Keywords

  • Colorectal cancer
  • LCT-13910C>T
  • Lactose intolerance
  • Polymorphism

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Tarabra, E., Pazienza, P., Borghesio, E., Actis, G. C., Tappero, G., Framarin, L., ... Rosina, F. (2010). LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy. Digestive and Liver Disease, 42(10), 741-743. https://doi.org/10.1016/j.dld.2010.02.013