LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

Elena Tarabra; Paola Pazienza; Elisabetta Borghesio; Giovanni C. Actis; Gianfranco Tappero; Luciana Framarin; Mohammad Ayoubi; Francesca Castellino; Nicola Leone; Giovanni Sansoè; Paolo De Paolis; Alessandro Comandone; Floriano Rosina

doi:10.1016/j.dld.2010.02.013

LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

Elena Tarabra, Paola Pazienza, Elisabetta Borghesio, Giovanni C. Actis, Gianfranco Tappero, Luciana Framarin, Mohammad Ayoubi, Francesca Castellino, Nicola Leone, Giovanni Sansoè, Paolo De Paolis, Alessandro Comandone, Floriano Rosina

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

Original language	English (US)
Pages (from-to)	741-743
Number of pages	3
Journal	Digestive and Liver Disease
Volume	42
Issue number	10
DOIs	https://doi.org/10.1016/j.dld.2010.02.013
State	Published - Oct 2010
Externally published	Yes

Keywords

Colorectal cancer
LCT-13910C>T
Lactose intolerance
Polymorphism

ASJC Scopus subject areas

Hepatology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dld.2010.02.013

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Tarabra, E., Pazienza, P., Borghesio, E., Actis, G. C., Tappero, G., Framarin, L., Ayoubi, M., Castellino, F., Leone, N., Sansoè, G., De Paolis, P., Comandone, A., & Rosina, F. (2010). LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy. Digestive and Liver Disease, 42(10), 741-743. https://doi.org/10.1016/j.dld.2010.02.013

Tarabra, E, Pazienza, P, Borghesio, E, Actis, GC, Tappero, G, Framarin, L, Ayoubi, M, Castellino, F, Leone, N, Sansoè, G, De Paolis, P, Comandone, A & Rosina, F 2010, 'LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy', Digestive and Liver Disease, vol. 42, no. 10, pp. 741-743. https://doi.org/10.1016/j.dld.2010.02.013

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title = "LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy",

abstract = "Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.",

keywords = "Colorectal cancer, LCT-13910C>T, Lactose intolerance, Polymorphism",

author = "Elena Tarabra and Paola Pazienza and Elisabetta Borghesio and Actis, {Giovanni C.} and Gianfranco Tappero and Luciana Framarin and Mohammad Ayoubi and Francesca Castellino and Nicola Leone and Giovanni Sanso{\`e} and {De Paolis}, Paolo and Alessandro Comandone and Floriano Rosina",

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doi = "10.1016/j.dld.2010.02.013",

language = "English (US)",

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TY - JOUR

T1 - LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

AU - Tarabra, Elena

AU - Pazienza, Paola

AU - Borghesio, Elisabetta

AU - Actis, Giovanni C.

AU - Tappero, Gianfranco

AU - Framarin, Luciana

AU - Ayoubi, Mohammad

AU - Castellino, Francesca

AU - Leone, Nicola

AU - Sansoè, Giovanni

AU - De Paolis, Paolo

AU - Comandone, Alessandro

AU - Rosina, Floriano

PY - 2010/10

Y1 - 2010/10

N2 - Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

AB - Background: The activity of epithelial lactase (LCT) associates with a polymorphism 13910. bp upstream the LCT-encoding gene (LCT-13910C> T). The relationship between LCT-13910C> T polymorphism and risk for colorectal cancer is unclear. Aims: We examined the relationship between the LCT-13910C> T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population. Patients and methods: 793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C> T variant by TaqMan real time-PCR. Results: Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR = 1.041; 95% CI = 0.751-1.442; p= 0.868) or polyps (OR = 0.927; 95% CI = 0.630-1.363; p= 0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype. Conclusion: In the Italian population the LCT-13910C> T polymorphism is not associated to the risk for colorectal cancer or polyps.

KW - Colorectal cancer

KW - LCT-13910C>T

KW - Lactose intolerance

KW - Polymorphism

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LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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