Large and small fibre type sensory dysfunction in patients with cancer

Richard B. Lipton, B. S. Galer, Joseph C. Arezzo, V. Pahmer, F. Meller, J. P. Dutcher, P. H. Wiernik, R. K. Portenoy

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Quantitative sensory testing was used to assess the prevalence of sensory dysfunction in patients with cancer, carefully screened for other risk factors for neuropathy. Large fibre type sensory function was evaluated using vibration threshold (VT) determinations while small fibre type sensory function was assessed by thermal threshold (TT) determinations. Mean VT and TT were significantly elevated in the toes but not the fingers of cancer patients. VT elevations in the toes occurred in 31% of cancer patients and in 6% of control subjects. TT elevations in the toes occurred in 43% of cancer patients and 4% of control subjects. Based on these findings it is concluded that large and small fibre type sensory dysfunction is much more common in carefully screened cancer patients than in control subjects. This sensory dysfunction is most likely to represent a neuropathy related directly or indirectly associated with cancer.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume54
Issue number8
DOIs
StatePublished - 1991

Fingerprint

Toes
Vibration
Neoplasms
Hot Temperature
Fingers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Large and small fibre type sensory dysfunction in patients with cancer. / Lipton, Richard B.; Galer, B. S.; Arezzo, Joseph C.; Pahmer, V.; Meller, F.; Dutcher, J. P.; Wiernik, P. H.; Portenoy, R. K.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 54, No. 8, 1991, p. 706-709.

Research output: Contribution to journalArticle

Lipton, Richard B. ; Galer, B. S. ; Arezzo, Joseph C. ; Pahmer, V. ; Meller, F. ; Dutcher, J. P. ; Wiernik, P. H. ; Portenoy, R. K. / Large and small fibre type sensory dysfunction in patients with cancer. In: Journal of Neurology, Neurosurgery and Psychiatry. 1991 ; Vol. 54, No. 8. pp. 706-709.
@article{610c4719da0845a89eef64b856f9d236,
title = "Large and small fibre type sensory dysfunction in patients with cancer",
abstract = "Quantitative sensory testing was used to assess the prevalence of sensory dysfunction in patients with cancer, carefully screened for other risk factors for neuropathy. Large fibre type sensory function was evaluated using vibration threshold (VT) determinations while small fibre type sensory function was assessed by thermal threshold (TT) determinations. Mean VT and TT were significantly elevated in the toes but not the fingers of cancer patients. VT elevations in the toes occurred in 31{\%} of cancer patients and in 6{\%} of control subjects. TT elevations in the toes occurred in 43{\%} of cancer patients and 4{\%} of control subjects. Based on these findings it is concluded that large and small fibre type sensory dysfunction is much more common in carefully screened cancer patients than in control subjects. This sensory dysfunction is most likely to represent a neuropathy related directly or indirectly associated with cancer.",
author = "Lipton, {Richard B.} and Galer, {B. S.} and Arezzo, {Joseph C.} and V. Pahmer and F. Meller and Dutcher, {J. P.} and Wiernik, {P. H.} and Portenoy, {R. K.}",
year = "1991",
doi = "10.1136/jnnp.54.8.706",
language = "English (US)",
volume = "54",
pages = "706--709",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Large and small fibre type sensory dysfunction in patients with cancer

AU - Lipton, Richard B.

AU - Galer, B. S.

AU - Arezzo, Joseph C.

AU - Pahmer, V.

AU - Meller, F.

AU - Dutcher, J. P.

AU - Wiernik, P. H.

AU - Portenoy, R. K.

PY - 1991

Y1 - 1991

N2 - Quantitative sensory testing was used to assess the prevalence of sensory dysfunction in patients with cancer, carefully screened for other risk factors for neuropathy. Large fibre type sensory function was evaluated using vibration threshold (VT) determinations while small fibre type sensory function was assessed by thermal threshold (TT) determinations. Mean VT and TT were significantly elevated in the toes but not the fingers of cancer patients. VT elevations in the toes occurred in 31% of cancer patients and in 6% of control subjects. TT elevations in the toes occurred in 43% of cancer patients and 4% of control subjects. Based on these findings it is concluded that large and small fibre type sensory dysfunction is much more common in carefully screened cancer patients than in control subjects. This sensory dysfunction is most likely to represent a neuropathy related directly or indirectly associated with cancer.

AB - Quantitative sensory testing was used to assess the prevalence of sensory dysfunction in patients with cancer, carefully screened for other risk factors for neuropathy. Large fibre type sensory function was evaluated using vibration threshold (VT) determinations while small fibre type sensory function was assessed by thermal threshold (TT) determinations. Mean VT and TT were significantly elevated in the toes but not the fingers of cancer patients. VT elevations in the toes occurred in 31% of cancer patients and in 6% of control subjects. TT elevations in the toes occurred in 43% of cancer patients and 4% of control subjects. Based on these findings it is concluded that large and small fibre type sensory dysfunction is much more common in carefully screened cancer patients than in control subjects. This sensory dysfunction is most likely to represent a neuropathy related directly or indirectly associated with cancer.

UR - http://www.scopus.com/inward/record.url?scp=0025785904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025785904&partnerID=8YFLogxK

U2 - 10.1136/jnnp.54.8.706

DO - 10.1136/jnnp.54.8.706

M3 - Article

C2 - 1658236

AN - SCOPUS:0025785904

VL - 54

SP - 706

EP - 709

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -