LAPping up dead cells to prevent lupus nephritis

a novel role for noncanonical autophagy in autoimmunity

Jeremy S. Leventhal, Michael J. Ross

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

The mechanisms underlying the development of systemic lupus erythematosus and lupus nephritis remain poorly understood. A recent study demonstrates that deficiencies in the immune system's ability to degrade scavenged dead cells via noncanonical autophagy is sufficient to break immune tolerance and produce features commonly seen in lupus, including circulating autoantibodies, inflammatory cytokines, and nephritis. This work provides a possible mechanism for the association of polymorphisms in autophagy genes with the risk of lupus.

Original languageEnglish (US)
Pages (from-to)238-239
Number of pages2
JournalKidney International
Volume90
Issue number2
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Lupus Nephritis
Autophagy
Immune Tolerance
Nephritis
Systemic Lupus Erythematosus
Autoantibodies
Immune System
Cytokines
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Nephrology

Cite this

LAPping up dead cells to prevent lupus nephritis : a novel role for noncanonical autophagy in autoimmunity. / Leventhal, Jeremy S.; Ross, Michael J.

In: Kidney International, Vol. 90, No. 2, 01.08.2016, p. 238-239.

Research output: Contribution to journalComment/debate

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