Laparoscopic-assisted versus open pancreaticoduodenectomy: Early favorable physical quality-of-life measures

Russell C. Langan, Jay A. Graham, Anne B. Chin, Aaron J. Rubinstein, Kesha Oza, Jeff A. Nusbaum, John Smirniotopoulos, Reilly Kayser, Reena Jha, Nadim Haddad, Firas Al-Kawas, John Carroll, Jane Hanna, Ann Parker, Waddah B. Al-Refaie, Lynt B. Johnson

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36 Citations (Scopus)

Abstract

Background We compared outcomes and postpancreatectomy quality of life (QOL) in paired cohorts of patients undergoing conventional open pancreaticoduodenectomy (OPD) or laparoscopic-assisted pancreaticoduodenectomy (LAPD). Methods Comparative analysis of QOL was performed in a matched cohort of 53 patients after OPD or LAPD between 2010 and 2013. The Medical Outcomes Study Short Form-36 Health Survey and the Karnofsky score were used. Results Physical component score, mental component score, and Karnofsky scores were calculated at multiple time points for OPD (n = 25) and LAPD (n = 28). Operative times, complications, and readmission rates were equivalent. Time to starting adjuvant therapy trended toward clinical importance in LAPD (61 vs 110 days, P =.0878). Duration of stay was less in LAPD (7.10 vs 9.44 days, P =.02). LAPD had a superior QOL centered on functional status compared with OPD (physical component score 49.09 vs 38.4, P =.04; Karnofsky 92.22 vs 66.92%, P =.003). These statistical differences were not observed beyond 6 months. Conclusion LAPD provided a more favorable QOL within the first 6 months and shorter length of stay compared with conventional OPD. LAPD may serve as an alternative operative therapy to potentially minimize delays in receipt of and enhance tolerability of adjuvant therapies.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalSurgery (United States)
Volume156
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

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Pancreaticoduodenectomy
Quality of Life
Operative Time
Complementary Therapies
Health Surveys
Length of Stay

ASJC Scopus subject areas

  • Surgery

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Laparoscopic-assisted versus open pancreaticoduodenectomy : Early favorable physical quality-of-life measures. / Langan, Russell C.; Graham, Jay A.; Chin, Anne B.; Rubinstein, Aaron J.; Oza, Kesha; Nusbaum, Jeff A.; Smirniotopoulos, John; Kayser, Reilly; Jha, Reena; Haddad, Nadim; Al-Kawas, Firas; Carroll, John; Hanna, Jane; Parker, Ann; Al-Refaie, Waddah B.; Johnson, Lynt B.

In: Surgery (United States), Vol. 156, No. 2, 2014, p. 379-384.

Research output: Contribution to journalArticle

Langan, RC, Graham, JA, Chin, AB, Rubinstein, AJ, Oza, K, Nusbaum, JA, Smirniotopoulos, J, Kayser, R, Jha, R, Haddad, N, Al-Kawas, F, Carroll, J, Hanna, J, Parker, A, Al-Refaie, WB & Johnson, LB 2014, 'Laparoscopic-assisted versus open pancreaticoduodenectomy: Early favorable physical quality-of-life measures', Surgery (United States), vol. 156, no. 2, pp. 379-384. https://doi.org/10.1016/j.surg.2014.03.018
Langan, Russell C. ; Graham, Jay A. ; Chin, Anne B. ; Rubinstein, Aaron J. ; Oza, Kesha ; Nusbaum, Jeff A. ; Smirniotopoulos, John ; Kayser, Reilly ; Jha, Reena ; Haddad, Nadim ; Al-Kawas, Firas ; Carroll, John ; Hanna, Jane ; Parker, Ann ; Al-Refaie, Waddah B. ; Johnson, Lynt B. / Laparoscopic-assisted versus open pancreaticoduodenectomy : Early favorable physical quality-of-life measures. In: Surgery (United States). 2014 ; Vol. 156, No. 2. pp. 379-384.
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abstract = "Background We compared outcomes and postpancreatectomy quality of life (QOL) in paired cohorts of patients undergoing conventional open pancreaticoduodenectomy (OPD) or laparoscopic-assisted pancreaticoduodenectomy (LAPD). Methods Comparative analysis of QOL was performed in a matched cohort of 53 patients after OPD or LAPD between 2010 and 2013. The Medical Outcomes Study Short Form-36 Health Survey and the Karnofsky score were used. Results Physical component score, mental component score, and Karnofsky scores were calculated at multiple time points for OPD (n = 25) and LAPD (n = 28). Operative times, complications, and readmission rates were equivalent. Time to starting adjuvant therapy trended toward clinical importance in LAPD (61 vs 110 days, P =.0878). Duration of stay was less in LAPD (7.10 vs 9.44 days, P =.02). LAPD had a superior QOL centered on functional status compared with OPD (physical component score 49.09 vs 38.4, P =.04; Karnofsky 92.22 vs 66.92{\%}, P =.003). These statistical differences were not observed beyond 6 months. Conclusion LAPD provided a more favorable QOL within the first 6 months and shorter length of stay compared with conventional OPD. LAPD may serve as an alternative operative therapy to potentially minimize delays in receipt of and enhance tolerability of adjuvant therapies.",
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T1 - Laparoscopic-assisted versus open pancreaticoduodenectomy

T2 - Early favorable physical quality-of-life measures

AU - Langan, Russell C.

AU - Graham, Jay A.

AU - Chin, Anne B.

AU - Rubinstein, Aaron J.

AU - Oza, Kesha

AU - Nusbaum, Jeff A.

AU - Smirniotopoulos, John

AU - Kayser, Reilly

AU - Jha, Reena

AU - Haddad, Nadim

AU - Al-Kawas, Firas

AU - Carroll, John

AU - Hanna, Jane

AU - Parker, Ann

AU - Al-Refaie, Waddah B.

AU - Johnson, Lynt B.

PY - 2014

Y1 - 2014

N2 - Background We compared outcomes and postpancreatectomy quality of life (QOL) in paired cohorts of patients undergoing conventional open pancreaticoduodenectomy (OPD) or laparoscopic-assisted pancreaticoduodenectomy (LAPD). Methods Comparative analysis of QOL was performed in a matched cohort of 53 patients after OPD or LAPD between 2010 and 2013. The Medical Outcomes Study Short Form-36 Health Survey and the Karnofsky score were used. Results Physical component score, mental component score, and Karnofsky scores were calculated at multiple time points for OPD (n = 25) and LAPD (n = 28). Operative times, complications, and readmission rates were equivalent. Time to starting adjuvant therapy trended toward clinical importance in LAPD (61 vs 110 days, P =.0878). Duration of stay was less in LAPD (7.10 vs 9.44 days, P =.02). LAPD had a superior QOL centered on functional status compared with OPD (physical component score 49.09 vs 38.4, P =.04; Karnofsky 92.22 vs 66.92%, P =.003). These statistical differences were not observed beyond 6 months. Conclusion LAPD provided a more favorable QOL within the first 6 months and shorter length of stay compared with conventional OPD. LAPD may serve as an alternative operative therapy to potentially minimize delays in receipt of and enhance tolerability of adjuvant therapies.

AB - Background We compared outcomes and postpancreatectomy quality of life (QOL) in paired cohorts of patients undergoing conventional open pancreaticoduodenectomy (OPD) or laparoscopic-assisted pancreaticoduodenectomy (LAPD). Methods Comparative analysis of QOL was performed in a matched cohort of 53 patients after OPD or LAPD between 2010 and 2013. The Medical Outcomes Study Short Form-36 Health Survey and the Karnofsky score were used. Results Physical component score, mental component score, and Karnofsky scores were calculated at multiple time points for OPD (n = 25) and LAPD (n = 28). Operative times, complications, and readmission rates were equivalent. Time to starting adjuvant therapy trended toward clinical importance in LAPD (61 vs 110 days, P =.0878). Duration of stay was less in LAPD (7.10 vs 9.44 days, P =.02). LAPD had a superior QOL centered on functional status compared with OPD (physical component score 49.09 vs 38.4, P =.04; Karnofsky 92.22 vs 66.92%, P =.003). These statistical differences were not observed beyond 6 months. Conclusion LAPD provided a more favorable QOL within the first 6 months and shorter length of stay compared with conventional OPD. LAPD may serve as an alternative operative therapy to potentially minimize delays in receipt of and enhance tolerability of adjuvant therapies.

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