TY - JOUR
T1 - Lack of Transmission of HTLV-III/LAV Infection to Household Contacts of Patients with AIDS or AIDS-Related Complex with Oral Candidiasis
AU - Friedland, Gerald H.
AU - Saltzman, Brian R.
AU - Rogers, Martha F.
AU - Kahl, Patricia A.
AU - Lesser, Martin L.
AU - Mayers, Marguerite M.
AU - Klein, Robert S.
PY - 1986/2/6
Y1 - 1986/2/6
N2 - To determine the risk of transmission of human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) to close but nonsexual contacts of patients with the acquired immunodeficiency syndrome (AIDS), we studied the nonsexual household contacts of patients with AIDS or the AIDS-related complex with oral candidiasis. Detailed interviews, physical examinations, and tests for serum antibody to HTLV-III/LAV were performed on 101 household contacts of 39 AIDS patients (68 children and 33 adults), all of whom had lived in the same household with an index patient for at least three months. These contacts had shared household items and facilities and had close personal interaction with the patient for a median of 22 months (range, 3 to 48) during the period of presumed infectivity. Only 1 of 101 household contacts — a five-year-old child — had evidence of infection with the virus, which had probably been acquired perinatally rather than through horizontal transmission. This study indicates that household contacts who are not sexual partners of, or born to, patients with AIDS are at minimal or no risk of infection with HTLV-III/LAV. (N Engl J Med 1986; 314:344–9.), Since the recognition of the epidemic of the acquired immunodeficiency syndrome (AIDS) in 1981, several populations have been described that are at increased risk of infection with the human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) and disease due to it. These include homosexual men,1 intravenous drug abusers,2 and recipients of transfusions of blood and blood products.3,4 In addition, transmission of HTLV-III/LAV infection to heterosexual partners of patients with AIDS5 and children born to mothers with AIDS or in high-risk groups has been described.6 The major routes of transmission of HTLV-III/LAV infection have been well established. Blood-borne transmission is supported.
AB - To determine the risk of transmission of human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) to close but nonsexual contacts of patients with the acquired immunodeficiency syndrome (AIDS), we studied the nonsexual household contacts of patients with AIDS or the AIDS-related complex with oral candidiasis. Detailed interviews, physical examinations, and tests for serum antibody to HTLV-III/LAV were performed on 101 household contacts of 39 AIDS patients (68 children and 33 adults), all of whom had lived in the same household with an index patient for at least three months. These contacts had shared household items and facilities and had close personal interaction with the patient for a median of 22 months (range, 3 to 48) during the period of presumed infectivity. Only 1 of 101 household contacts — a five-year-old child — had evidence of infection with the virus, which had probably been acquired perinatally rather than through horizontal transmission. This study indicates that household contacts who are not sexual partners of, or born to, patients with AIDS are at minimal or no risk of infection with HTLV-III/LAV. (N Engl J Med 1986; 314:344–9.), Since the recognition of the epidemic of the acquired immunodeficiency syndrome (AIDS) in 1981, several populations have been described that are at increased risk of infection with the human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) and disease due to it. These include homosexual men,1 intravenous drug abusers,2 and recipients of transfusions of blood and blood products.3,4 In addition, transmission of HTLV-III/LAV infection to heterosexual partners of patients with AIDS5 and children born to mothers with AIDS or in high-risk groups has been described.6 The major routes of transmission of HTLV-III/LAV infection have been well established. Blood-borne transmission is supported.
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U2 - 10.1056/NEJM198602063140604
DO - 10.1056/NEJM198602063140604
M3 - Article
C2 - 3456076
AN - SCOPUS:0022577943
SN - 0028-4793
VL - 314
SP - 344
EP - 349
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 6
ER -
