L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants

Candice D. Fike, Marshall Summar, Judy L. Aschner

Research output: Contribution to journalReview article

19 Scopus citations


Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production. Conclusion: Strategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)1019-1026
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics
Issue number10
Publication statusPublished - Oct 1 2014



  • Bronchopulmonary dysplasia
  • Nitric oxide
  • Oxidative stress
  • Premature infants
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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