L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants

Candice D. Fike, Marshall Summar, Judy L. Aschner

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

UNLABELLED: Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production.

CONCLUSION: Strategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)1019-1026
Number of pages8
JournalActa Paediatrica, International Journal of Paediatrics
Volume103
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Citrulline
Pulmonary Hypertension
Nitric Oxide
Newborn Infant
Newborn Animals
Arginine
Therapeutics

Keywords

  • Bronchopulmonary dysplasia
  • Nitric oxide
  • Oxidative stress
  • Premature infants
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants. / Fike, Candice D.; Summar, Marshall; Aschner, Judy L.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 103, No. 10, 01.10.2014, p. 1019-1026.

Research output: Contribution to journalArticle

Fike, Candice D. ; Summar, Marshall ; Aschner, Judy L. / L-citrulline provides a novel strategy for treating chronic pulmonary hypertension in newborn infants. In: Acta Paediatrica, International Journal of Paediatrics. 2014 ; Vol. 103, No. 10. pp. 1019-1026.
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