Abstract
Effective therapies are urgently needed for infants with forms of pulmonary hypertension that develop or persist beyond the first week of life. The L-arginine nitric oxide (NO) precursor, L-citrulline, improves NO signalling and ameliorates pulmonary hypertension in newborn animals. In vitro studies demonstrate that manipulating L-citrulline transport alters NO production. Conclusion: Strategies that increase the supply and transport of L-citrulline merit pursuit as novel approaches to managing infants with chronic, progressive pulmonary hypertension.
Original language | English (US) |
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Pages (from-to) | 1019-1026 |
Number of pages | 8 |
Journal | Acta Paediatrica, International Journal of Paediatrics |
Volume | 103 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2014 |
Keywords
- Bronchopulmonary dysplasia
- Nitric oxide
- Oxidative stress
- Premature infants
- Pulmonary hypertension
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health