L-2-Oxothiazolidine-4-Carboxylate and N-Acetylcysteine as Precursors of Intracellular Glutathione in Human Peritoneal Mesothelial Cells

Andrzej Breborowicz, Athina Patrikarea, Leo Martis, D. G. Oreopoulos

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

L-2-Oxothiazolidine-4-carboxylate and N-acetylcysteine as substrates for intracellular glutathione in human peritoneal mesothelial cells were tested. Both substances at concentrations of 0.01 mM and higher augmented the level of glutathione in mesothelial cells. L-2-Oxothiazolidine-4-carboxylate had a milder but more stable effect than N-acetylcysteine. Cells with increased concentrations of the intracellular glutathione were more resistant to injury by free radicals. When used at higher concentrations (> 1 mM), both substances became cytostatic to mesothelial cells as evidenced by growth inhibition.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBlood Purification
Volume14
Issue number1
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Glutathione
  • L-2-Oxothiazolidine-4-carboxylate
  • Mesothelium
  • N-Acetylcysteine

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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