Abstract
L-2-Oxothiazolidine-4-carboxylate and N-acetylcysteine as substrates for intracellular glutathione in human peritoneal mesothelial cells were tested. Both substances at concentrations of 0.01 mM and higher augmented the level of glutathione in mesothelial cells. L-2-Oxothiazolidine-4-carboxylate had a milder but more stable effect than N-acetylcysteine. Cells with increased concentrations of the intracellular glutathione were more resistant to injury by free radicals. When used at higher concentrations (> 1 mM), both substances became cytostatic to mesothelial cells as evidenced by growth inhibition.
Original language | English (US) |
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Pages (from-to) | 1-7 |
Number of pages | 7 |
Journal | Blood Purification |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1996 |
Externally published | Yes |
Keywords
- Glutathione
- L-2-Oxothiazolidine-4-carboxylate
- Mesothelium
- N-Acetylcysteine
ASJC Scopus subject areas
- Hematology
- Nephrology