Knotted proteins

Olesya V. Stepanenko, G. S. Bublikov, Olga V. Stepanenko, G. N. Rychkov, O. I. Povarova, Vladislav Verkhusha, K. K. Turoverov, I. M. Kuznetsova

Research output: Contribution to journalArticle

Abstract

For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalTsitologiya
Volume57
Issue number3
StatePublished - 2015
Externally publishedYes

Fingerprint

Protein Folding
Proteins
Peptides
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stepanenko, O. V., Bublikov, G. S., Stepanenko, O. V., Rychkov, G. N., Povarova, O. I., Verkhusha, V., ... Kuznetsova, I. M. (2015). Knotted proteins. Tsitologiya, 57(3), 177-183.

Knotted proteins. / Stepanenko, Olesya V.; Bublikov, G. S.; Stepanenko, Olga V.; Rychkov, G. N.; Povarova, O. I.; Verkhusha, Vladislav; Turoverov, K. K.; Kuznetsova, I. M.

In: Tsitologiya, Vol. 57, No. 3, 2015, p. 177-183.

Research output: Contribution to journalArticle

Stepanenko, OV, Bublikov, GS, Stepanenko, OV, Rychkov, GN, Povarova, OI, Verkhusha, V, Turoverov, KK & Kuznetsova, IM 2015, 'Knotted proteins', Tsitologiya, vol. 57, no. 3, pp. 177-183.
Stepanenko OV, Bublikov GS, Stepanenko OV, Rychkov GN, Povarova OI, Verkhusha V et al. Knotted proteins. Tsitologiya. 2015;57(3):177-183.
Stepanenko, Olesya V. ; Bublikov, G. S. ; Stepanenko, Olga V. ; Rychkov, G. N. ; Povarova, O. I. ; Verkhusha, Vladislav ; Turoverov, K. K. ; Kuznetsova, I. M. / Knotted proteins. In: Tsitologiya. 2015 ; Vol. 57, No. 3. pp. 177-183.
@article{9a07bf867bd441a886c1d05438c9a7d1,
title = "Knotted proteins",
abstract = "For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.",
author = "Stepanenko, {Olesya V.} and Bublikov, {G. S.} and Stepanenko, {Olga V.} and Rychkov, {G. N.} and Povarova, {O. I.} and Vladislav Verkhusha and Turoverov, {K. K.} and Kuznetsova, {I. M.}",
year = "2015",
language = "English (US)",
volume = "57",
pages = "177--183",
journal = "Tsitologiya",
issn = "0041-3771",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "3",

}

TY - JOUR

T1 - Knotted proteins

AU - Stepanenko, Olesya V.

AU - Bublikov, G. S.

AU - Stepanenko, Olga V.

AU - Rychkov, G. N.

AU - Povarova, O. I.

AU - Verkhusha, Vladislav

AU - Turoverov, K. K.

AU - Kuznetsova, I. M.

PY - 2015

Y1 - 2015

N2 - For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

AB - For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

UR - http://www.scopus.com/inward/record.url?scp=84930793234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930793234&partnerID=8YFLogxK

M3 - Article

C2 - 26021166

AN - SCOPUS:84930793234

VL - 57

SP - 177

EP - 183

JO - Tsitologiya

JF - Tsitologiya

SN - 0041-3771

IS - 3

ER -