Knotted proteins

Olesya V. Stepanenko; G. S. Bublikov; Olga V. Stepanenko; G. N. Rychkov; O. I. Povarova; V. V. Verkhusha; K. K. Turoverov; I. M. Kuznetsova

Knotted proteins

Olesya V. Stepanenko, G. S. Bublikov, Olga V. Stepanenko, G. N. Rychkov, O. I. Povarova, V. V. Verkhusha, K. K. Turoverov, I. M. Kuznetsova

Genetics

Research output: Contribution to journal › Review article › peer-review

Abstract

For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

Original language	English (US)
Pages (from-to)	177-183
Number of pages	7
Journal	Tsitologiia
Volume	57
Issue number	3
State	Published - 2015

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

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title = "Knotted proteins",

abstract = "For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.",

author = "Stepanenko, {Olesya V.} and Bublikov, {G. S.} and Stepanenko, {Olga V.} and Rychkov, {G. N.} and Povarova, {O. I.} and Verkhusha, {V. V.} and Turoverov, {K. K.} and Kuznetsova, {I. M.}",

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language = "English (US)",

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T1 - Knotted proteins

AU - Stepanenko, Olesya V.

AU - Bublikov, G. S.

AU - Stepanenko, Olga V.

AU - Rychkov, G. N.

AU - Povarova, O. I.

AU - Verkhusha, V. V.

AU - Turoverov, K. K.

AU - Kuznetsova, I. M.

PY - 2015

Y1 - 2015

N2 - For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

AB - For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.

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M3 - Review article

C2 - 26021166

AN - SCOPUS:84930793234

SN - 0041-3771

VL - 57

SP - 177

EP - 183

JO - Tsitologiia

JF - Tsitologiia

IS - 3

ER -

Knotted proteins

Abstract

ASJC Scopus subject areas

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