Knockdown of carboxypeptidase A6 in zebrafish larvae reduces response to seizure-inducing drugs and causes changes in the level of mRNAs encoding signaling molecules

Medicine & Life Sciences

• zebrafish carboxypeptidase A6 100%
• Pilocarpine 49%
• Larva 42%
• Seizures 31%
• Carboxypeptidases 29%
• Messenger RNA 22%
• Zebrafish 20%
• Pentylenetetrazole 16%
• Pharmaceutical Preparations 16%
• human carboxypeptidase A6 16%
• Neuropeptides 13%
• 3-nitro-2-pyridinesulfenyl 11%
• Extracellular Matrix 11%
• Mutation 11%
• Juvenile Myoclonic Epilepsy 10%
• Morpholinos 8%
• Febrile Seizures 8%
• Haploinsufficiency 8%
• Temporal Lobe Epilepsy 7%
• Loss of Function Mutation 7%
• Swimming 7%
• Embryonic Structures 5%
• Transcription Factors 5%
• Amino Acids 4%
• Peptides 4%
• Enzymes 3%
• Genes 2%
• Proteins 2%

Agriculture & Biology

• pilocarpine 55%
• carboxypeptidases 51%
• seizures 45%
• Danio rerio 41%
• drugs 26%
• larvae 23%
• epilepsy 17%
• neuropeptides 14%
• extracellular matrix 13%
• mutation 13%
• metallocarboxypeptidases 11%
• haploinsufficiency 11%
• loss-of-function mutation 8%
• fever 6%
• inheritance (genetics) 5%
• transcription factors 5%
• embryo (animal) 4%
• peptides 4%
• amino acids 3%
• enzymes 2%
• genes 2%
• proteins 2%

Chemical Compounds

• Pilocarpine 60%
• Signalling Molecule 50%
• Mutation 22%
• Drug 21%
• Enzyme Activity 5%
• Resistance 4%
• Peptide 3%
• Reduction 3%
• Protein 2%
• Acid 2%
• Molecule 2%