Is cancer vaccination feasible at older age?

Claudia Gravekamp, Arthee Jahangir

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of both innate and adaptive immune responses for cancer immunotherapy. These analyses suggest that creating an immune-stimulating environment with help of the innate immune system may improve T cell responses in cancer vaccination at older age.

Original languageEnglish (US)
Pages (from-to)138-144
Number of pages7
JournalExperimental Gerontology
Volume54
DOIs
StatePublished - 2014

Fingerprint

T-cells
Vaccination
T-Lymphocytes
Immune system
Immune System
Neoplasms
Defects
Cancer Vaccines
Tumor Microenvironment
Viral Tumor Antigens
Adaptive Immunity
Antigen-Presenting Cells
Innate Immunity
Immunotherapy
Tumors
Chemical activation

Keywords

  • Adaptive immune system
  • Aging
  • Cancer immunotherapy
  • Cancer vaccines
  • Immune system
  • Innate immune system

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Is cancer vaccination feasible at older age? / Gravekamp, Claudia; Jahangir, Arthee.

In: Experimental Gerontology, Vol. 54, 2014, p. 138-144.

Research output: Contribution to journalArticle

Gravekamp, Claudia ; Jahangir, Arthee. / Is cancer vaccination feasible at older age?. In: Experimental Gerontology. 2014 ; Vol. 54. pp. 138-144.
@article{46d8a4e8700c46f7a13137acd64ed74b,
title = "Is cancer vaccination feasible at older age?",
abstract = "Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of both innate and adaptive immune responses for cancer immunotherapy. These analyses suggest that creating an immune-stimulating environment with help of the innate immune system may improve T cell responses in cancer vaccination at older age.",
keywords = "Adaptive immune system, Aging, Cancer immunotherapy, Cancer vaccines, Immune system, Innate immune system",
author = "Claudia Gravekamp and Arthee Jahangir",
year = "2014",
doi = "10.1016/j.exger.2014.01.025",
language = "English (US)",
volume = "54",
pages = "138--144",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Is cancer vaccination feasible at older age?

AU - Gravekamp, Claudia

AU - Jahangir, Arthee

PY - 2014

Y1 - 2014

N2 - Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of both innate and adaptive immune responses for cancer immunotherapy. These analyses suggest that creating an immune-stimulating environment with help of the innate immune system may improve T cell responses in cancer vaccination at older age.

AB - Age-related defects of the immune system are responsible for T cell unresponsiveness to cancer vaccination at older age. Major immune defects at older age are lack of naive T cells, impaired activation pathways of T cells and antigen-presenting cells (APCs), and age-related changes in the tumor microenvironment (TME). This raises the question whether cancer vaccination is feasible at older age. We compared various cancer vaccine studies at young and old age, thereby focusing on the importance of both innate and adaptive immune responses for cancer immunotherapy. These analyses suggest that creating an immune-stimulating environment with help of the innate immune system may improve T cell responses in cancer vaccination at older age.

KW - Adaptive immune system

KW - Aging

KW - Cancer immunotherapy

KW - Cancer vaccines

KW - Immune system

KW - Innate immune system

UR - http://www.scopus.com/inward/record.url?scp=84898842511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898842511&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2014.01.025

DO - 10.1016/j.exger.2014.01.025

M3 - Article

C2 - 24509231

AN - SCOPUS:84898842511

VL - 54

SP - 138

EP - 144

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -