IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention

The POUNDS LOST trial

Qibin Qi, Min Xu, Hongyu Wu, Liming Liang, Catherine M. Champagne, George A. Bray, Frank M. Sacks, Lu Qi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE-Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODSdTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake frombaseline) varying in macronutrient contents for 2 years.We comparedMetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers). RESULTS-Among rs1522813 A-allele carriers, the reversion rates of theMetSwere higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groupswas observed among noncarriers (P = 0.27).The geneticmodulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95%CI 1.25-6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36-1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status. CONCLUSIONS-Our data suggest that high-fat weight-loss diets might bemore effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.

Original languageEnglish (US)
Pages (from-to)3442-3447
Number of pages6
JournalDiabetes Care
Volume36
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

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Reducing Diet
Alleles
Fat-Restricted Diet
Genotype
Energy Intake
Fats
High Fat Diet
Diet
Odds Ratio
Weight Loss
Weights and Measures

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing
  • Medicine(all)

Cite this

IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention : The POUNDS LOST trial. / Qi, Qibin; Xu, Min; Wu, Hongyu; Liang, Liming; Champagne, Catherine M.; Bray, George A.; Sacks, Frank M.; Qi, Lu.

In: Diabetes Care, Vol. 36, No. 11, 11.2013, p. 3442-3447.

Research output: Contribution to journalArticle

Qi, Qibin ; Xu, Min ; Wu, Hongyu ; Liang, Liming ; Champagne, Catherine M. ; Bray, George A. ; Sacks, Frank M. ; Qi, Lu. / IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention : The POUNDS LOST trial. In: Diabetes Care. 2013 ; Vol. 36, No. 11. pp. 3442-3447.
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title = "IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention: The POUNDS LOST trial",
abstract = "OBJECTIVE-Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODSdTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake frombaseline) varying in macronutrient contents for 2 years.We comparedMetS status of high-fat (40{\%} of caloric intake; n = 370) and low-fat (20{\%} caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers). RESULTS-Among rs1522813 A-allele carriers, the reversion rates of theMetSwere higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groupswas observed among noncarriers (P = 0.27).The geneticmodulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95{\%}CI 1.25-6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36-1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status. CONCLUSIONS-Our data suggest that high-fat weight-loss diets might bemore effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.",
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T1 - IRS1 genotype modulates metabolic syndrome reversion in response to 2-year weight-loss diet intervention

T2 - The POUNDS LOST trial

AU - Qi, Qibin

AU - Xu, Min

AU - Wu, Hongyu

AU - Liang, Liming

AU - Champagne, Catherine M.

AU - Bray, George A.

AU - Sacks, Frank M.

AU - Qi, Lu

PY - 2013/11

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N2 - OBJECTIVE-Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODSdTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake frombaseline) varying in macronutrient contents for 2 years.We comparedMetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers). RESULTS-Among rs1522813 A-allele carriers, the reversion rates of theMetSwere higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groupswas observed among noncarriers (P = 0.27).The geneticmodulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95%CI 1.25-6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36-1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status. CONCLUSIONS-Our data suggest that high-fat weight-loss diets might bemore effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.

AB - OBJECTIVE-Genetic variants near IRS1 are associated with features of the metabolic syndrome (MetS). We examined whether genetic variants near IRS1 might modulate the effects of diets varying in fat content on the MetS status in a 2-year weight-loss trial. RESEARCH DESIGN AND METHODSdTwo variants near IRS1, rs1522813 and rs2943641, were genotyped in 738 overweight/obese adults (age 60 ± 9 years; BMI 32.7 ± 3.9 kg/m2) randomly assigned to one of four weight-loss diets (a deficit of 750 kcal/day of caloric intake frombaseline) varying in macronutrient contents for 2 years.We comparedMetS status of high-fat (40% of caloric intake; n = 370) and low-fat (20% caloric intake; n = 368) diet groups differentiated by genotypes (rs1522813 A-allele carriers and noncarriers and rs2943641T-allele carriers and noncarriers). RESULTS-Among rs1522813 A-allele carriers, the reversion rates of theMetSwere higher in the high-fat diet group than those in the low-fat diet group over the 2-year intervention (P = 0.002), while no significant difference between diet groupswas observed among noncarriers (P = 0.27).The geneticmodulation on dietary effect was independent of weight changes. The odds ratio (OR) for the 2-year reversion of the MetS was 2.88 (95%CI 1.25-6.67) comparing the high-fat and low-fat diets among rs1522813 A-allele carriers, while the corresponding OR was 0.83 (0.36-1.92) in noncarriers. The variant rs2943641 was not observed to modulate dietary effects on the MetS status. CONCLUSIONS-Our data suggest that high-fat weight-loss diets might bemore effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1.

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