Iron deficiency anemia in Helicobacter pylori infection

Meta-analysis of randomized controlled trials

Yuan Wenzhen, Li Yumin, Yang Kehu, Ma Bin, Guan Quanlin, Wang Donghai, Yang Lijuan

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Background. Helicobacter pylori (H. pylori) infection and iron deficiency anemia are prevalent in disadvantaged populations worldwide. The benefit of H. pylori eradiation for iron deficiency anemia has been extensively studied, but data are still equivocal. Methods. A search in The Cochrane Library, PUBMED, EMBASE, EBM Review databases, Science Citation Index Expanded, and CMB (Chinese Biomedical Literature Database) was performed. Randomized controlled trials (RCTs) comparing anti-H. pylori plus oral iron to oral iron alone for the iron deficiency patients in whom H. pylori was positive were selected for meta-analysis. Reviev Manager 5.0 software was used for the performance of meta-analysis. Results. Sixteen randomized controlled trials totaling 956 patients were included. The meta-analysis showed that the difference from baseline to endpoint of hemoglobin (Hb), serum iron (SI), and serum ferritin (SF) was statistically significantly different between anti-H. pylori treatment plus oral iron and oral iron alone (SMD, Hb 1.48; 95% CI, 0.96, 2.00; p < 0.00001; SI 1.15; 95% CI, 0.87, 1.43; p < 0.00001; SF 1.84; 95% CI, 1.20, 2.48; p < 0.00001, respectively). Conclusions. Our study suggests that treatment of H. pylori infection could be effective in improving anemia and iron statue in IDA patients infected by H. pylori, particularly in patients with moderate or severe anemia.

Original languageEnglish (US)
Pages (from-to)665-676
Number of pages12
JournalScandinavian Journal of Gastroenterology
Volume45
Issue number6
DOIs
StatePublished - Jun 2010

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Iron-Deficiency Anemias
Helicobacter Infections
Helicobacter pylori
Meta-Analysis
Iron
Randomized Controlled Trials
Ferritins
Serum
Anemia
Hemoglobins
Databases
Vulnerable Populations
Libraries
Software
Therapeutics

Keywords

  • Helicobacter pylori
  • Iron deficiency anemia
  • Meta-analysis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Iron deficiency anemia in Helicobacter pylori infection : Meta-analysis of randomized controlled trials. / Wenzhen, Yuan; Yumin, Li; Kehu, Yang; Bin, Ma; Quanlin, Guan; Donghai, Wang; Lijuan, Yang.

In: Scandinavian Journal of Gastroenterology, Vol. 45, No. 6, 06.2010, p. 665-676.

Research output: Contribution to journalArticle

Wenzhen, Yuan ; Yumin, Li ; Kehu, Yang ; Bin, Ma ; Quanlin, Guan ; Donghai, Wang ; Lijuan, Yang. / Iron deficiency anemia in Helicobacter pylori infection : Meta-analysis of randomized controlled trials. In: Scandinavian Journal of Gastroenterology. 2010 ; Vol. 45, No. 6. pp. 665-676.
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