TY - JOUR
T1 - Irinotecan for pediatric solid tumors
T2 - The memorial sloan-kettering experience
AU - Cosetti, Maura
AU - Wexler, Leonard H.
AU - Calleja, Elizabeth
AU - Trippett, Tanya
AU - LaQuaglia, Michael
AU - Huvos, Andrew G.
AU - Gerald, William
AU - Healey, John H.
AU - Meyers, Paul A.
AU - Gorlick, Richard
PY - 2002
Y1 - 2002
N2 - Purpose Irinotecan is a novel antineoplastic agent that works by inhibiting the enzyme, topoisomerase 1. Although not extensively studied in children, preclinical studies and several phase 1 trials indicate activity against a variety of relapsed solid tumors when administered on a protracted schedule. This report describes an institutional experience with irinotecan for the treatment of pediatric solid tumors. Patients and Methods Twenty-two heavily pretreated children with multiply relapsed tumors were treated with courses of irinotecan at 20 mg/m2 per day for 10 days [(every day × 5) × 2]. Results Of the 19 patients evaluable for response, four achieved an objective response, including two complete responses and one partial response among four patients with rhabdomyosarcoma and one additional patient with an undifferentiated sarcoma with rhabdomyoblastic features, and one patient with a fibrosarcoma had stable disease. Among three patients with non-Hodgkin lymphoma, one achieved a partial response and one had stable disease. Diarrhea was the most commonly observed toxicity. Conclusion Irinotecan appears to have promising single-agent activity, particularly against rhabdomyosarcoma, with minimal hematopoietic toxicity, making it ideal for further evaluation in patients at high risk with newly diagnosed disease, particularly in combination with other active agents with nonoverlapping toxicities.
AB - Purpose Irinotecan is a novel antineoplastic agent that works by inhibiting the enzyme, topoisomerase 1. Although not extensively studied in children, preclinical studies and several phase 1 trials indicate activity against a variety of relapsed solid tumors when administered on a protracted schedule. This report describes an institutional experience with irinotecan for the treatment of pediatric solid tumors. Patients and Methods Twenty-two heavily pretreated children with multiply relapsed tumors were treated with courses of irinotecan at 20 mg/m2 per day for 10 days [(every day × 5) × 2]. Results Of the 19 patients evaluable for response, four achieved an objective response, including two complete responses and one partial response among four patients with rhabdomyosarcoma and one additional patient with an undifferentiated sarcoma with rhabdomyoblastic features, and one patient with a fibrosarcoma had stable disease. Among three patients with non-Hodgkin lymphoma, one achieved a partial response and one had stable disease. Diarrhea was the most commonly observed toxicity. Conclusion Irinotecan appears to have promising single-agent activity, particularly against rhabdomyosarcoma, with minimal hematopoietic toxicity, making it ideal for further evaluation in patients at high risk with newly diagnosed disease, particularly in combination with other active agents with nonoverlapping toxicities.
KW - Irinotecan
KW - Pediatric malignancy
KW - Rhabdomyosarcoma
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U2 - 10.1097/00043426-200202000-00009
DO - 10.1097/00043426-200202000-00009
M3 - Article
C2 - 11990694
AN - SCOPUS:0036171172
SN - 0192-8562
VL - 24
SP - 101
EP - 105
JO - American Journal of Pediatric Hematology/Oncology
JF - American Journal of Pediatric Hematology/Oncology
IS - 2
ER -