Ipsilateral hand input to area 3b revealed by converging hemodynamic and electrophysiological analyses in macaque monkeys

Michael L. Lipton, Kai Ming G Fu, Craig A. Branch, Charles E. Schroeder

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Functional magnetic resonance imaging (fMRI) of the hand representation in primary somatosensory cortex (area 3b) of macaque monkeys revealed an ipsilateral hand input undetected by most previous studies. Ipsilateral responses had a hemodynamic signature indistinguishable from that of contralateral hand responses. We explored the neural mechanisms of the fMRI effects using a second derivative analysis of field potentials [current source density (CSD) analysis] combined with action potential profiles, sampled from area 3b using linear array multielectrodes. In contrast to the predominantly excitatory contralateral response, the colocated ipsilateral response appeared dominated by inhibition, suggesting that ipsilateral inputs may have modulatory effects on contralateral input processing. Our findings confirm bimanual convergence at the earliest stage of cortical somatosensory processing in primates. They also illustrate the value of combined CSD and fMRI analyses in monkeys for defining hidden aspects of sensory function and for investigating the neuronal processes generating fMRI signals.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalJournal of Neuroscience
Volume26
Issue number1
DOIs
StatePublished - Jan 4 2006
Externally publishedYes

Fingerprint

Macaca
Haplorhini
Hand
Hemodynamics
Magnetic Resonance Imaging
Somatosensory Cortex
Primates
Action Potentials

Keywords

  • Cortical feedback
  • fMRI
  • Inhibition
  • Ipsilateral response
  • Monkey area 3b
  • Somatosensory physiology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ipsilateral hand input to area 3b revealed by converging hemodynamic and electrophysiological analyses in macaque monkeys. / Lipton, Michael L.; Fu, Kai Ming G; Branch, Craig A.; Schroeder, Charles E.

In: Journal of Neuroscience, Vol. 26, No. 1, 04.01.2006, p. 180-185.

Research output: Contribution to journalArticle

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