Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent

Nina Singh, Timothy Gayowski, Marilyn M. Wagener, Howard Doyle, Ignazio R. Marino

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Invasive fungal infections and their risk factors were prospectively assessed in 130 consecutive liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. Eleven percent (14) of the 130 patients had 17 episodes of invasive fungal infections. These included candidiasis (5%; 6 patients), cryptococcosis (5%; 6), aspergillosis (3%; 4), and chromomycosis (1%; 1). An elevated pretransplantation creatinine level, requirement of dialysis (pretransplantation or posttransplantation), duration of intensive care unit stay after transplantation surgery, and antibiotic use (other than for prophylaxis) within 4 weeks of transplantation were significant risk factors for fungal infections occurring within 100 days of transplantation. For fungal infections occurring after 100 days, persistence of renal dysfunction (serum creatinine level of >2.5 mg/dL at 3 months), dialysis, and histopathologically documented recurrence of hepatitis C virus hepatitis were significant risk factors. Mortality was significantly higher among patients with fungal infections than among all other patients (57% vs. 15%; P = .0009). Our study identified specific risk factors for invasive fungal infections in liver transplant recipients receiving tacrolimus; strategies to prevent fungal infections or to initiate early antifungal therapy might be most effectively targeted at these patients.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalClinical Infectious Diseases
Volume24
Issue number2
StatePublished - 1997
Externally publishedYes

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Tacrolimus
Immunosuppressive Agents
Mycoses
Liver
Transplantation
Dialysis
Creatinine
Chromoblastomycosis
Cryptococcosis
Aspergillosis
Candidiasis
Secondary Prevention
Hepacivirus
Hepatitis
Intensive Care Units
Invasive Fungal Infections
Transplant Recipients
Anti-Bacterial Agents
Kidney
Recurrence

ASJC Scopus subject areas

  • Immunology

Cite this

Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. / Singh, Nina; Gayowski, Timothy; Wagener, Marilyn M.; Doyle, Howard; Marino, Ignazio R.

In: Clinical Infectious Diseases, Vol. 24, No. 2, 1997, p. 179-184.

Research output: Contribution to journalArticle

Singh, Nina ; Gayowski, Timothy ; Wagener, Marilyn M. ; Doyle, Howard ; Marino, Ignazio R. / Invasive fungal infections in liver transplant recipients receiving tacrolimus as the primary immunosuppressive agent. In: Clinical Infectious Diseases. 1997 ; Vol. 24, No. 2. pp. 179-184.
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