Invasive aspergillosis of the lung and pericardium in a nonimmunocompromised 33 year old man

J. Allen D Cooper, David L. Weinbaum, Thomas K. Aldrich, Gerald L. Mandell

Research output: Contribution to journalArticle

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Abstract

In a 33 year old man with no discernible immunologic defect, invasive aspergillosis developed in both the pericardium and lung with marked granulomatous reaction. The patient received 2 g of intravenous amphotericin B over eight weeks, with partial regression of the pulmonary infiltrate and disappearance of symptoms. However, five months later, he returned with marked progression of his disease. Evaluation of host defense, including granulocyte and lymphocyte function, was normal. The patient was given an additional 3 g of amphotericin B over nine weeks with marked improvement in symptoms and chest roentgenogram. At six-month follow-up, he was asymptomatic with a stable radiographic appearance. A recurrence in symptoms and the pulmonary infiltrate was noted two months later. He was treated with an additional course of amphotericin and currently is receiving ketoconazole in hopes of suppressing the infection. We could find no immune impairment to explain the severe pulmonary and pericardial disease due to Aspergillus flavus in this young man.

Original languageEnglish (US)
Pages (from-to)903-907
Number of pages5
JournalThe American journal of medicine
Volume71
Issue number5
DOIs
StatePublished - 1981
Externally publishedYes

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Pulmonary Aspergillosis
Pericardium
Amphotericin B
Lung
Aspergillus flavus
Ketoconazole
Aspergillosis
Granulocytes
Lung Diseases
Disease Progression
Thorax
Lymphocytes
Recurrence
Infection

ASJC Scopus subject areas

  • Nursing(all)

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Invasive aspergillosis of the lung and pericardium in a nonimmunocompromised 33 year old man. / Cooper, J. Allen D; Weinbaum, David L.; Aldrich, Thomas K.; Mandell, Gerald L.

In: The American journal of medicine, Vol. 71, No. 5, 1981, p. 903-907.

Research output: Contribution to journalArticle

Cooper, J. Allen D ; Weinbaum, David L. ; Aldrich, Thomas K. ; Mandell, Gerald L. / Invasive aspergillosis of the lung and pericardium in a nonimmunocompromised 33 year old man. In: The American journal of medicine. 1981 ; Vol. 71, No. 5. pp. 903-907.
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