Invadopodia and podosomes in tumor invasion

Hideki Yamaguchi, Fiona Pixley, John S. Condeelis

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Cell migration through the extracellular matrix (ECM) is necessary for cancer cells to invade adjacent tissues and metastasize to an organ distant from primary tumors. Highly invasive carcinoma cells form ECM-degrading membrane protrusions called invadopodia. Tumor-associated macrophages have been shown to promote the migratory phenotypes of carcinoma cells, and macrophages are known to form podosomes, similar structures to invadopodia. However, the role of invadopodia and podosomes in vivo remains to be determined. In this paper, we propose a model for possible functions and interactions of invadopodia and podosomes in tumor invasion, based on observations that macrophage podosomes degrade ECM and that podosome formation is regulated by colony-stimulating factor-1 signaling.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalEuropean Journal of Cell Biology
Volume85
Issue number3-4
DOIs
StatePublished - Apr 7 2006

Fingerprint

Neoplasms
Extracellular Matrix
Macrophages
Carcinoma
Podosomes
Macrophage Colony-Stimulating Factor
Cell Movement
Phenotype
Membranes

Keywords

  • Carcinoma
  • CSF-1
  • EGF
  • Invadopodia
  • Invasion
  • Macrophage
  • Metastasis
  • N-WASP
  • Podosomes
  • WASP

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Invadopodia and podosomes in tumor invasion. / Yamaguchi, Hideki; Pixley, Fiona; Condeelis, John S.

In: European Journal of Cell Biology, Vol. 85, No. 3-4, 07.04.2006, p. 213-218.

Research output: Contribution to journalArticle

Yamaguchi, Hideki ; Pixley, Fiona ; Condeelis, John S. / Invadopodia and podosomes in tumor invasion. In: European Journal of Cell Biology. 2006 ; Vol. 85, No. 3-4. pp. 213-218.
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