Intraperitoneal administration of recombinant human erythropoietin in uremic animals

J. M. Bargman; A. Breborowicz; H. Rodela; K. Sombolos; D. G. Oreopoulos

doi:10.1177/089686088800800404

Intraperitoneal administration of recombinant human erythropoietin in uremic animals

J. M. Bargman, A. Breborowicz, H. Rodela, K. Sombolos, D. G. Oreopoulos

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.

Original language	English (US)
Pages (from-to)	249-252
Number of pages	4
Journal	Peritoneal Dialysis International
Volume	8
Issue number	4
DOIs	https://doi.org/10.1177/089686088800800404
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/089686088800800404

Cite this

@article{73a83d59262d460e9419c13805652865,

title = "Intraperitoneal administration of recombinant human erythropoietin in uremic animals",

abstract = "Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.",

author = "Bargman, {J. M.} and A. Breborowicz and H. Rodela and K. Sombolos and Oreopoulos, {D. G.}",

year = "1988",

doi = "10.1177/089686088800800404",

language = "English (US)",

volume = "8",

pages = "249--252",

journal = "Peritoneal Dialysis International",

issn = "0896-8608",

publisher = "Multimed Inc.",

number = "4",

}

TY - JOUR

T1 - Intraperitoneal administration of recombinant human erythropoietin in uremic animals

AU - Bargman, J. M.

AU - Breborowicz, A.

AU - Rodela, H.

AU - Sombolos, K.

AU - Oreopoulos, D. G.

PY - 1988

Y1 - 1988

N2 - Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.

AB - Previous protocols of administration of recombinant human erythropoietin to patients with end-stage renal disease have been by the i.v. route. Because this method would be impractical for the continuous ambulatory peritoneal dialysis patient, we designed an i.p. dosing protocol in uremic rabbits to examine whether significant amounts of this hormone could be absorbed from the peritoneal cavity. Our results demonstrate that almost all of the erythropoietin is absorbed (or absorbed) during a prolonged dwell when administered undiluted by dialysate.

UR - http://www.scopus.com/inward/record.url?scp=0024208370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024208370&partnerID=8YFLogxK

U2 - 10.1177/089686088800800404

DO - 10.1177/089686088800800404

M3 - Article

AN - SCOPUS:0024208370

SN - 0896-8608

VL - 8

SP - 249

EP - 252

JO - Peritoneal Dialysis International

JF - Peritoneal Dialysis International

IS - 4

ER -

Intraperitoneal administration of recombinant human erythropoietin in uremic animals

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this