Intracranial pressure during nitroglycerin-induced hypotension

J. E. Cottrell, B. Gupta, H. Rappaport, H. Turndorf, J. Ransohoff, Eugene S. Flamm

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Nitroglycerin was given intravenously to 5 anesthetized, hyperventilated (PaCO 2 25 to 30 torr) patients during craniotomy, to facilitate surgery by creating a relatively bloodless field, and to decrease the potential need for blood transfusion. A subarachnoid screw and an indwelling radial artery catheter were inserted to monitor intracranial pressure (ICP) and mean arterial pressure (MAP). As MAP decreased from 104.4 ± 4.0 (SE) to 69.0 ± 1.8 torr, ICP increased from 14.2 ± 0.7 (SEM) to 30.8 ± 1.1 torr. Cerebral perfusion pressure decreased from 90.2 ± 3.6 (SEM) to 38.2 ± 2.3 torr (p < 0.0005). The authors attribute this nitroglycerin-induced ICP increase to capacitance vessel dilation within the relatively noncompliant cranial cavity, with subsequent cerebral blood volume increase.

Original languageEnglish (US)
Pages (from-to)309-311
Number of pages3
JournalJournal of Neurosurgery
Volume53
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Controlled Hypotension
Nitroglycerin
Intracranial Pressure
Cerebrovascular Circulation
Arterial Pressure
Radial Artery
Intracranial Hypertension
Craniotomy
Blood Transfusion
Dilatation
Catheters

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cottrell, J. E., Gupta, B., Rappaport, H., Turndorf, H., Ransohoff, J., & Flamm, E. S. (1980). Intracranial pressure during nitroglycerin-induced hypotension. Journal of Neurosurgery, 53(3), 309-311.

Intracranial pressure during nitroglycerin-induced hypotension. / Cottrell, J. E.; Gupta, B.; Rappaport, H.; Turndorf, H.; Ransohoff, J.; Flamm, Eugene S.

In: Journal of Neurosurgery, Vol. 53, No. 3, 1980, p. 309-311.

Research output: Contribution to journalArticle

Cottrell, JE, Gupta, B, Rappaport, H, Turndorf, H, Ransohoff, J & Flamm, ES 1980, 'Intracranial pressure during nitroglycerin-induced hypotension', Journal of Neurosurgery, vol. 53, no. 3, pp. 309-311.
Cottrell JE, Gupta B, Rappaport H, Turndorf H, Ransohoff J, Flamm ES. Intracranial pressure during nitroglycerin-induced hypotension. Journal of Neurosurgery. 1980;53(3):309-311.
Cottrell, J. E. ; Gupta, B. ; Rappaport, H. ; Turndorf, H. ; Ransohoff, J. ; Flamm, Eugene S. / Intracranial pressure during nitroglycerin-induced hypotension. In: Journal of Neurosurgery. 1980 ; Vol. 53, No. 3. pp. 309-311.
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