Intracranial metastasis in fibrolamellar hepatocellular carcinoma

William J. Hammond; Gadi Lalazar; James A. Saltsman; Benjamin A. Farber; Enrico Danzer; Tshering C. Sherpa; Charles D. Banda; Jeffrey R. Andolina; Sasan Karimi; Cameron W. Brennan; Michael S. Torbenson; Michael P. La Quaglia; Sanford M. Simon

doi:10.1002/pbc.26919

Intracranial metastasis in fibrolamellar hepatocellular carcinoma

William J. Hammond, Gadi Lalazar, James A. Saltsman, Benjamin A. Farber, Enrico Danzer, Tshering C. Sherpa, Charles D. Banda, Jeffrey R. Andolina, Sasan Karimi, Cameron W. Brennan, Michael S. Torbenson, Michael P. La Quaglia, Sanford M. Simon

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.

Original language	English (US)
Article number	e26919
Journal	Pediatric Blood and Cancer
Volume	65
Issue number	4
DOIs	https://doi.org/10.1002/pbc.26919
State	Published - Apr 2018
Externally published	Yes

Keywords

adolescent and young adult tumors
brain
fibrolamellar
liver
rare tumors
tumor biology
tumors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.26919

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@article{3ce3b34e520c4f3c8e2fb428941e8a47,

title = "Intracranial metastasis in fibrolamellar hepatocellular carcinoma",

abstract = "Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.",

keywords = "adolescent and young adult tumors, brain, fibrolamellar, liver, rare tumors, tumor biology, tumors",

author = "Hammond, {William J.} and Gadi Lalazar and Saltsman, {James A.} and Farber, {Benjamin A.} and Enrico Danzer and Sherpa, {Tshering C.} and Banda, {Charles D.} and Andolina, {Jeffrey R.} and Sasan Karimi and Brennan, {Cameron W.} and Torbenson, {Michael S.} and {La Quaglia}, {Michael P.} and Simon, {Sanford M.}",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2018",

month = apr,

doi = "10.1002/pbc.26919",

language = "English (US)",

volume = "65",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

number = "4",

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TY - JOUR

T1 - Intracranial metastasis in fibrolamellar hepatocellular carcinoma

AU - Hammond, William J.

AU - Lalazar, Gadi

AU - Saltsman, James A.

AU - Farber, Benjamin A.

AU - Danzer, Enrico

AU - Sherpa, Tshering C.

AU - Banda, Charles D.

AU - Andolina, Jeffrey R.

AU - Karimi, Sasan

AU - Brennan, Cameron W.

AU - Torbenson, Michael S.

AU - La Quaglia, Michael P.

AU - Simon, Sanford M.

PY - 2018/4

Y1 - 2018/4

N2 - Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.

AB - Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.

KW - adolescent and young adult tumors

KW - brain

KW - fibrolamellar

KW - liver

KW - rare tumors

KW - tumor biology

KW - tumors

UR - http://www.scopus.com/inward/record.url?scp=85039728150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039728150&partnerID=8YFLogxK

U2 - 10.1002/pbc.26919

DO - 10.1002/pbc.26919

M3 - Article

C2 - 29286561

AN - SCOPUS:85039728150

SN - 1545-5009

VL - 65

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 4

M1 - e26919

ER -

Intracranial metastasis in fibrolamellar hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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