Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms

Medicine & Life Sciences

• Intraventricular Infusions 82%
• Leptin 58%
• Homeostasis 42%
• Glucose 36%
• Liver 30%
• Insulin Resistance 21%
• Skeletal Muscle 15%
• Eating 14%
• mouse insulin-like growth factor-1 12%
• Triglycerides 10%
• Somatomedin Receptors 8%
• Indirect Calorimetry 8%
• Glucose Clamp Technique 7%
• Vagotomy 7%
• Adipokines 7%
• Nonesterified Fatty Acids 6%
• Adiposity 6%
• Oxygen Consumption 6%
• Weight Gain 5%
• Type 2 Diabetes Mellitus 4%
• Fats 4%
• Body Weight 4%
• Insulin 4%
• Serum 2%

Agriculture & Biology

• leptin 67%
• homeostasis 50%
• glucose 35%
• liver 34%
• mice 33%
• insulin resistance 31%
• skeletal muscle 17%
• glucose tolerance 17%
• food intake 17%
• triacylglycerols 10%
• adipokines 9%
• insulin-like growth factor I receptor 9%
• adiposity 8%
• noninsulin-dependent diabetes mellitus 8%
• calorimetry 7%
• energy balance 6%
• oxygen consumption 6%
• free fatty acids 5%
• animal models 5%
• insulin 5%
• weight gain 5%
• oxidation 4%
• body weight 4%
• lipids 3%

Chemical Compounds

• Leptin 100%
• Intracerebroventricular 93%
• Glucose 43%
• Insulin Derivative 33%
• Food 13%
• Triglyceride 13%
• Hyperlipidemic 10%
• Hyperglycemic 10%
• Energy Balance 8%
• Weight Gain 8%
• Fat 6%
• Calorimetry 6%
• Resistance 4%
• Dioxygen 3%
• Reduction 2%
• Oxidation Reaction 2%