Intracellular peptides: From discovery to function

Emer S. Ferro, Vanessa Rioli, Leandro M. Castro, Lloyd D. Fricker

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Peptidomics techniques have identified hundreds of peptides that are derived from proteins present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular peptides to distinguish them from secretory pathway peptides that function primarily outside of the cell. The proteasome and thimet oligopeptidase participate in the production and metabolism of intracellular peptides. Many of the intracellular peptides are common among mouse tissues and human cell lines analyzed and likely to perform a variety of functions within cells. Demonstrated functions include the modulation of signal transduction, mitochondrial stress, and development; additional functions will likely be found for intracellular peptides.

Original languageEnglish (US)
Pages (from-to)143-151
Number of pages9
JournalEuPA Open Proteomics
Volume3
DOIs
StatePublished - 2014

Fingerprint

Peptides
thimet oligopeptidase
Signal transduction
Mitochondria
Secretory Pathway
Proteasome Endopeptidase Complex
Metabolism
Cytosol
Signal Transduction
Cells
Modulation
Tissue
Cell Line
Proteins

Keywords

  • Cell signaling
  • Mass spectrometry
  • Peptides
  • Peptidomics
  • Protein-protein interaction
  • Receptors

ASJC Scopus subject areas

  • Biochemistry

Cite this

Intracellular peptides : From discovery to function. / Ferro, Emer S.; Rioli, Vanessa; Castro, Leandro M.; Fricker, Lloyd D.

In: EuPA Open Proteomics, Vol. 3, 2014, p. 143-151.

Research output: Contribution to journalArticle

Ferro, Emer S. ; Rioli, Vanessa ; Castro, Leandro M. ; Fricker, Lloyd D. / Intracellular peptides : From discovery to function. In: EuPA Open Proteomics. 2014 ; Vol. 3. pp. 143-151.
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